{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:18:06Z","timestamp":1767651486681,"version":"3.40.5"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T00:00:00Z","timestamp":1688860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effect of sodium thiosulfate (STS) on serum calcification factors in patients undergoing maintenance hemodialysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010four Patients were randomly divided into control group (<jats:italic>n<\/jats:italic>\u2009=\u200922) and observation group (<jats:italic>n<\/jats:italic>\u2009=\u200922) by envelope method (block 4 randomization). The control group received routine treatment while observation group was treated with STS on the basis of routine treatment. The biochemical indicators, including BUN, UA, SCr, Ca<jats:sup>2+<\/jats:sup>, P<jats:sup>3\u2212<\/jats:sup>, calcium\u2010phosphorus product, PTH, hs\u2010CRP, TG, TC, HDL, LDL, and serum calcification factor MGP, FA, FGF\u201023, and OPG levels were compared before and after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Control group had no statistically significant difference in the levels of vascular calcification factors MGP, FA, FGF\u201023, and OPG before and after treatment (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Whereas observation group had higher levels of MGP and FA, and lower levels of FGF\u201023 and OPG after treatment than before treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The levels of MGP and FA in observation group were higher than those in control group, and FGF\u201023 and OPG were lower than those in control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It is speculated that sodium thiosulfate can alleviate the progression of vascular calcification by changing the levels of calcification factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.14029","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T06:49:19Z","timestamp":1688971759000},"page":"1079-1087","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of sodium thiosulfate on serum calcification factors in patients undergoing maintenance hemodialysis"],"prefix":"10.1111","volume":"27","author":[{"given":"Pan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Nephrology The 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