{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T23:38:18Z","timestamp":1771544298911,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hospitalization for decompensated heart failure is a major public health issue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a meta\u2010analysis to summarize and analyze if there is a benefit in using ultrafiltration over diuretics in terms of reducing mortality or hospital readmissions, primarily and identified 10 randomized controlled trials (RCTs) including 941 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to diuretics, treatment with ultrafiltration was associated with a significant reduction in heart failure hospitalizations (risk ratio [RR]: 0.72; 95% confidence interval [CI]: 0.55\u20130.96, <jats:italic>p<\/jats:italic>\u2009=\u20090.02) and significant increase in weight and net fluid loss (mean difference [MD]: \u22121.55, CI: \u22122.36 to \u22120.74, <jats:italic>p<\/jats:italic>\u2009=\u20090.0002) and (MD: \u22122.10, CI: \u22123.32 to \u22120.89, <jats:italic>p<\/jats:italic>\u2009=\u20090.0007), respectively. There was no significant difference among treatments regarding the duration of hospitalization, the increase in serum creatinine levels, and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among patients with decompensated heart failure, compared to diuretics, ultrafiltration is associated with reduced rehospitalizations and increased weight\/net fluid loss.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.14037","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T06:26:01Z","timestamp":1689834361000},"page":"9-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diuretics or ultrafiltration in the treatment of acute decompensated heart failure: An updated systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"28","author":[{"given":"Vasileios","family":"Terpos","sequence":"first","affiliation":[{"name":"Section of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9423-649X","authenticated-orcid":false,"given":"Stefanos","family":"Roumeliotis","sequence":"additional","affiliation":[{"name":"Section of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiotis I.","family":"Georgianos","sequence":"additional","affiliation":[{"name":"Section of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni","family":"Papa","sequence":"additional","affiliation":[{"name":"Section of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios G.","family":"Tsalikakis","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering University of Western Macedonia  Kozani Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelos","family":"Papachristou","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplantation Patras University Hospital  Patras Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vassilios","family":"Liakopoulos","sequence":"additional","affiliation":[{"name":"Section of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.592"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.12.038"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.08.019"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/sui008"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000164149"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.108.821785"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.215"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.12.059"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.170"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.01.067"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-5299.2002.0758.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2019.01.007"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(93)90119-A"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01479-6"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000047399"},{"key":"e_1_2_8_17_1","unstructured":"Clinicaltrials.gov [Internet].2021. Available from:https:\/\/clinicaltrials.gov\/ct2\/results?term=ultrafiltration&cond=Heart+Failure&recrs=g&recrs=h&age_v=&gndr=&type=&rslt=&Search=Apply"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-020-01733-5"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2015.08.005"},{"issue":"25","key":"e_1_2_8_21_1","first-page":"79","article-title":"Comparison of ultrafiltration and intravenous diuretic therapies in patients hospitalized for acute decompensated biventricular heart failure","volume":"2016","author":"\u015eeker A","year":"2016","journal-title":"Turkish J Nephrol"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2013.11.004"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7133.2011.00231.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1210357"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2011.05.013"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq207"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.073"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.05.098"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2014.44.3.156"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_8_31_1","unstructured":"Cochrane handbook for systematic reviews of interventions version 6.2 (updated February 2021). Cochrane 2021.2021."},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.08.005"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.885210"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192064"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2009.12.009"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-022-02227-w"},{"issue":"4","key":"e_1_2_8_37_1","first-page":"340","article-title":"Safety and efficacy of ultrafiltration on heart failure patients with reduced ejection fraction and diuretic resistance: results from a single\u2010center randomized controlled trial","volume":"49","author":"Shen XL","year":"2021","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"issue":"4","key":"e_1_2_8_38_1","first-page":"400","article-title":"The effects of ultrafiltration and diuretic therapies on oxidative stress markers in patients with cardio\u2010renal syndrome","volume":"69","author":"Sav T","year":"2017","journal-title":"Minerva Urol Nefrol"},{"issue":"5","key":"e_1_2_8_39_1","article-title":"Ultrafiltration treatment in decompensated heart failure: changes in heart rate variability and survival","volume":"58","author":"Stein AC","year":"2011","journal-title":"Hypertension"},{"issue":"2","key":"e_1_2_8_40_1","first-page":"30","article-title":"Application of methods of renal replacement therapy for abolishment of hyperhydration in patients with decompensated chronic heart failure. [Russian]","volume":"50","author":"Tabak'ian EA","year":"2010","journal-title":"Kardiologiia"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2014.10.005"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.07.023"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005419"},{"issue":"1","key":"e_1_2_8_44_1","article-title":"Ultrafiltration for acute heart failure","volume":"1","author":"Srivastava M","year":"2022","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-020-10057-7"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-019-09812-2"},{"issue":"11","key":"e_1_2_8_47_1","first-page":"763","article-title":"Body fluid withdrawal with isolated ultrafiltration effects persistent improvement of functional capacity in patients with chronic congestive heart failure. Furosemide does not produce the same result. [Italian] La rimozione di liquido corporeo con ultrafiltrazione isolata produce persistente miglioramento della capacita funzionale del soggetto con insufficienza cardiaca congestizia cronica. La furosemide non da lo stesso risultato","volume":"39","author":"Marenzi G","year":"1994","journal-title":"Cardiologia"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivs492"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.54.390"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015385.2017.1291195"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.109.883256"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1744-9987.14037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T03:07:12Z","timestamp":1705547232000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1744-9987.14037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,19]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/1744-9987.14037"],"URL":"https:\/\/doi.org\/10.1111\/1744-9987.14037","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,19]]},"assertion":[{"value":"2022-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}