{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T10:25:56Z","timestamp":1776075956224,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:00:00Z","timestamp":1692316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>For safe management of cell\u2010free and concentrated ascites reinfusion therapy (CART), a highly reliable leak test for detecting ascites filter damage is essential. However, such a test has not been established for drop\u2010type CART.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We devised two novel leak tests for drop\u2010 and external pressure\u2010type CART, manual or pump pressurization methods, using high\u2010pressure loading and pressure monitoring, and investigated their reliability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both methods could easily load and maintain sufficiently high pressure (&gt;400\u2009Torr) on the hollow fibers for 2\u2009min. No result deviation was noted between different operators. The pressure drops in both methods were identical and significantly lower than those in the leak test using a special CART machine, the e\u2010CART.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The reliability of our revised leak test is equivalent to that of the automatic leak test of e\u2010CART. These highly reliable leak tests may contribute to safety in patients undergoing drop\u2010 and external pressure\u2010type CART.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.14048","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T17:56:39Z","timestamp":1692640599000},"page":"1040-1047","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Novel and highly reliable leak check tests for drop\u2010 and external pressure\u2010type cell\u2010free and concentrated ascites reinfusion therapy"],"prefix":"10.1111","volume":"27","author":[{"given":"Yasuko","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Department of Clinical Engineering Shinshu University Hospital  Matsumoto Nagano Japan"},{"name":"Division of Blood Purification Shinshu University Hospital  Matsumoto Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nana","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineering Shinshu University Hospital  Matsumoto Nagano Japan"},{"name":"Division of Blood Purification Shinshu University Hospital  Matsumoto Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamami","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineering Shinshu University Hospital  Matsumoto Nagano Japan"},{"name":"Division of Blood Purification Shinshu University Hospital  Matsumoto Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Minowa","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineering Shinshu University Hospital  Matsumoto Nagano Japan"},{"name":"Division of Blood Purification Shinshu University Hospital  Matsumoto Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Michinaga","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineering Shinshu University Hospital  Matsumoto Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Inui","sequence":"additional","affiliation":[{"name":"Division of Blood Purification Shinshu University Hospital  Matsumoto Nagano Japan"},{"name":"Department of Nephrology Shinshu University School of Medicine  Matsumoto Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shinshu University School of Medicine  Matsumoto Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Kamijo","sequence":"additional","affiliation":[{"name":"Division of Blood Purification Shinshu University Hospital  Matsumoto Nagano Japan"},{"name":"Department of Nephrology Shinshu University School of Medicine  Matsumoto Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177303"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002480-197700230-00189"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2017.08.018"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12049"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2014.335"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.13747"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09298-6"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15620"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13681"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.13658"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12933"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12821"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12829"},{"key":"e_1_2_10_15_1","unstructured":"Japanese Society of Apheresis.Safety standard of CART [Internet]. Available from:https:\/\/www.apheresis-jp.org\/110790.html"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46774-9"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12560"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1744-9987.14048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T04:25:25Z","timestamp":1706675125000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1744-9987.14048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,18]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/1744-9987.14048"],"URL":"https:\/\/doi.org\/10.1111\/1744-9987.14048","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,18]]},"assertion":[{"value":"2022-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}