{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:29:12Z","timestamp":1747182552022,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2024,2]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Simple plasma exchange (PE) with fresh\u2010frozen plasma replacement allows antibody removal for ABO\u2010incompatible living donor kidney transplantation, but is associated with a high incidence of allergic reactions. We developed, implemented, and evaluated a protocol for safe preoperative PE.<\/jats:p><\/jats:sec>Methods<\/jats:title>The protocol comprised pretreatment (125\u2009mg methylprednisolone infusion, 400\u2009mg acetaminophen and 30\u2009mg diphenhydramine orally) with a replacement fluid rate\u2009<\u200920\u2009mL\/min. Allergic reaction incidence was investigated in controls who underwent ABO\u2010incompatible living donor kidney transplantation between 2016 and March 2020 (group C) and patients who underwent the protocol and procedure between April 2020 and February 2023 (group N).<\/jats:p><\/jats:sec>Results<\/jats:title>Ten (group C) and 19 (group N) patients performed 11 and 30 sessions of PE, respectively. Allergic reactions occurred in 81.8% and 36.7% (p<\/jats:italic>\u2009=\u20090.014), respectively, with an odds ratio of the protocol was 0.056 (95% CI 0.0059\u20130.5380, P\u2009=\u20090.013).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our protocol resulted in a significantly lower incidence of allergic reactions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.14071","type":"journal-article","created":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T03:46:32Z","timestamp":1696045592000},"page":"152-157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Establishment of an adverse effect prevention protocol on plasma exchange using fresh frozen plasma prior to ABO<\/scp>\u2010incompatible living donor kidney transplantation at our hospital"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8866-5901","authenticated-orcid":false,"given":"Akihito","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Nephrology Nagoya University Hospital Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Nephrology Nagoya University Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2476-688X","authenticated-orcid":false,"given":"Kazuhiro","family":"Furuhashi","sequence":"additional","affiliation":[{"name":"Department of Nephrology Nagoya University Hospital Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Nephrology Nagoya University Hospital Nagoya 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