{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:32:36Z","timestamp":1791217956621,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>A novel LDL (low\u2010density lipoprotein) apheresis therapeutic option, Rheocarna, has garnered attention as an alternative therapy for chronic limb\u2010threating ischemia (CLTI). Bradykinin\u2010mediated vasodilation is involved in the effects of LDL apheresis and a decrease in blood pressure (BP), but the changes in bradykinin concentration during Rheocarna therapy are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study involved patients with CLTI treated with Rheocarna at our hospital, from April 2022 to August 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After Rheocarna therapy, skin ulcers improved in 80% of the patients. Circuit coagulation was observed in two patients with high fibrinogen levels. A decrease in BP was observed at approximately the same time when the bradykinin concentration peaked. The peak bradykinin concentration in a patient undergoing hemodialysis at the same time was considerably lower than that in the other patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first report on the changes in bradykinin concentration under Rheocarna therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.14105","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T05:29:30Z","timestamp":1704346170000},"page":"453-459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Correlation between bradykinin concentration and blood pressure during <scp>Rheocarna<\/scp> therapy: <scp>A<\/scp> single\u2010center case series"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1287-2821","authenticated-orcid":false,"given":"Takaya","family":"Handa","sequence":"first","affiliation":[{"name":"Department of Nephrology and Dialysis Medical Research Institute Kitano Hospital, PIIF Tazuke\u2010Kofukai  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineering Medical Research Institute Kitano Hospital, PIIF Tazuke\u2010Kofukai  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masumi","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of the Blood Purification Center of Kitano Hospital Medical Research Institute Kitano Hospital, PIIF Tazuke\u2010Kofukai  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of the Blood Purification Center of Kitano Hospital Medical Research Institute Kitano Hospital, PIIF Tazuke\u2010Kofukai  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Sokai","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineering Medical Research Institute Kitano Hospital, PIIF Tazuke\u2010Kofukai  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineering Medical Research Institute Kitano Hospital, PIIF Tazuke\u2010Kofukai  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yui","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Dialysis Medical Research Institute Kitano Hospital, PIIF Tazuke\u2010Kofukai  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Ohue","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Dialysis Medical Research Institute Kitano Hospital, PIIF Tazuke\u2010Kofukai  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Higashi","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Dialysis Medical Research Institute Kitano Hospital, PIIF Tazuke\u2010Kofukai  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita P.","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Dialysis Medical Research Institute Kitano Hospital, PIIF Tazuke\u2010Kofukai  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Dialysis Medical Research Institute Kitano Hospital, PIIF Tazuke\u2010Kofukai  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Dialysis Medical Research Institute Kitano Hospital, PIIF Tazuke\u2010Kofukai  Osaka 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Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1744-9987.14105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T01:01:50Z","timestamp":1714352510000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1744-9987.14105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,3]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/1744-9987.14105"],"URL":"https:\/\/doi.org\/10.1111\/1744-9987.14105","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,3]]},"assertion":[{"value":"2023-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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