{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:52:45Z","timestamp":1770065565215,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>There is little evidence for ivabradine hydrochloride in patients undergoing hemodialysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this open\u2010label prospective interventional trial of hemodialysis patients with chronic heart failure, during 12\u2009weeks of treatment, changes in Heart rate (HR), frequency of dialysis\u2010related hypotension were examined, and we investigated health\u2010related quality of life (HR\u2010QOL) and adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>18 patients from 6 facilities were enrolled in the study. HR significantly decreased over time, from 87\u2009\u00b1\u200912.61\/min at baseline to 75.85\u2009\u00b1\u20098.91\/min (<jats:italic>p<\/jats:italic>\u2009=\u20090.0003), and systolic blood pressure also increased significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). The frequency of dialysis\u2010related hypotension was markedly reduced (<jats:italic>p<\/jats:italic>\u2009=\u20090.0001). The HR\u2010QOL survey showed significant improvements in Social Functioning among others (<jats:italic>p<\/jats:italic>\u2009=\u20090.0178). No specific adverse events occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ivabradine hydrochloride improved dialysis\u2010related hypotension. Furthermore, the HR\u2010QOL improvement effect were suggested. These results demonstrated the safety and effectiveness of ivabradine hydrochloride.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.14107","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:54:35Z","timestamp":1704934475000},"page":"354-363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The efficacy and safety of ivabradine hydrochloride in hemodialysis patients with chronic heart failure"],"prefix":"10.1111","volume":"28","author":[{"given":"Sayuri","family":"Kawasaki","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Metabolism and Nephrology, Graduate School of Medicine Nippon Medical School  Tokyo Japan"},{"name":"Akihabara Kidney Clinic  Tokyo Japan"},{"name":"Ayase\u2010ekimae Kidney Clinic  Tokyo 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