{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T20:39:02Z","timestamp":1787690342073,"version":"build-2784847793"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>To explore the effect of CRRT using CVVHDF\u2009+\u2009HP on the removal of inflammatory mediators in patients with septic shock complicated with AKI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 20 patients between January 1, 2018, and December 31, 2021, were included. The patients were randomly divided into the treatment group (CVVHDF\u2009+\u2009HP) and the control group (CVVHDF). Changes in inflammatory factors, including IL\u20101\u03b2, IL\u20106, IL\u20108, TNF\u2010\u03b1, PCT, and CRP were compared. Other observed measures were also analyzed, for example, Lac, Scr, BUN, SOFA, and norepinephrine (NE) dosage. The clinical outcomes of both groups were followed up for 28\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The IL\u20106 and PCT levels in the treatment group were significantly lower (<jats:italic>p<\/jats:italic>\u2009=\u20090.005, 0.007). Although the IL\u20101\u03b2, TNF\u03b1, and CRP levels in the treatment group decreased, there were no statistical differences (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). There were significant differences in Lac, SOFA, and NE dosage levels between both groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.023, 0.01, 0.023). Survival analysis showed that the 28\u2010day survival rate was significantly higher in the treatment group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CRRT using CVVHDF+HP can effectively remove inflammatory factors and improve the prognosis of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.14108","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T06:29:03Z","timestamp":1707287343000},"page":"460-466","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Removal of inflammatory factors and prognosis of patients with septic shock complicated with acute kidney injury by hemodiafiltration combined with <scp>HA330\u2010II<\/scp> hemoperfusion"],"prefix":"10.1111","volume":"28","author":[{"given":"Juan","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of ICU Tongji Hospital, School of Medicine, Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4896-0294","authenticated-orcid":false,"given":"Haopeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology Tongji Hospital, School of Medicine, Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of ICU Tongji Hospital, School of Medicine, Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangjian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of ICU Tongji Hospital, School of Medicine, Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of ICU Tongji Hospital, School of Medicine, Tongji University  Shanghai 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