{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:32:36Z","timestamp":1791217956747,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Rheocarna's therapeutic effect is associated with fibrinogen (Fib) and low\u2010density lipoprotein cholesterol (LDL\u2010C) adsorptive removal. This study aimed to retrospectively investigate the association between treatment volume (TV) and circulating blood volume (CBV) and the Fib removal rate (Fib\u2010RR) and LDL\u2010C\u2010RR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>CBV and TV\/CBV, cut\u2010off value (CO value), and area under the receiver operating characteristic (ROC) curve (AUC) were calculated. The Fib\u2010RR and LDL\u2010C\u2010RR at the midterm and end of treatment were compared. The groups were further categorized into three groups with TV\/CBV lower than or higher than the CO value at the midterm and end (midterm\/end; Group L: lower than\/lower than CO; Group L\/H: lower than\/higher than CO; Group H: higher than\/higher than CO), and the Fib\u2010RR and LDL\u2010RR of each group at the midterm and end were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ROC analysis revealed a TV of 1.480 times the BV as CO value, which showed a maximum Youden index predicting a Fib\u2010RR of 20% (AUC: 0.828). Among the three groups, Group L and Group L\/H demonstrated significantly higher Fib\u2010RR and LDL\u2010C\u2010RR at the end of the study than in the midterm, while Group H exhibited no difference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results reveal that a treatment volume of 1.5 times the circulating blood volume is a sufficient solute removal capacity in the Rheocarna\u2010enabled cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.14117","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T03:04:50Z","timestamp":1709867090000},"page":"505-510","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Investigation of treatment volume versus circulating blood volume during Rheocarna treatment"],"prefix":"10.1111","volume":"28","author":[{"given":"Yuki","family":"Hoshikawa","sequence":"first","affiliation":[{"name":"Medical Engineering Center Tokyo Medical and Dental University Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Ohkubo","sequence":"additional","affiliation":[{"name":"Medical Engineering Center Tokyo Medical and Dental University Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takatoshi","family":"Sakurasawa","sequence":"additional","affiliation":[{"name":"Medical Engineering Center Tokyo Medical and Dental University Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mana","family":"Usui","sequence":"additional","affiliation":[{"name":"Medical Engineering Center Tokyo Medical and Dental University Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Deushi","sequence":"additional","affiliation":[{"name":"Medical Engineering Center Tokyo Medical and Dental University Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Medical Engineering Center Tokyo Medical and Dental University Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of Nephrology Tokyo Medical and Dental University  Tokyo 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Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1744-9987.14117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T03:27:32Z","timestamp":1720063652000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1744-9987.14117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,7]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/1744-9987.14117"],"URL":"https:\/\/doi.org\/10.1111\/1744-9987.14117","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,7]]},"assertion":[{"value":"2023-12-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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