{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:26:33Z","timestamp":1747182393230,"version":"3.40.5"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T00:00:00Z","timestamp":1715472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The Seraph 100 Microbind Affinity blood filter eliminate bacteria, viruses, fungi and toxins from blood stream.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a prospective multicenter observational biomarker trial in PCR\u2010positive SARS\u2010CoV\u20102 patients with acute respiratory failure. Biomarkers were sequentially tested at three time points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010two patients with SARS\u2010CoV\u20102 detected by PCR with acute respiratory failure were included. When receiving hemoperfusion treatment, 27 (64%) patients were on mechanical ventilation, 41 (98%) patients were treated in the ICU. The 3\u2010month survival was 52%. After one hemoperfusion treatment cycle, D\u2010dimer (<jats:italic>p<\/jats:italic>\u2009=\u20090.014), hemoglobin (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) and LDH (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) concentrations were significantly reduced 4\u2009days after treatment. From the multiplex assay IL\u20101b, CXCL8\/ IL\u20108, IL\u201010, IL\u201013, IL\u201015, CCL11\/Eotaxin, G\u2010CSF, and CXCL10\/IP\u201010 were significantly reduced 1\u2009h after treatment, however not 4\u2009days later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hemoperfusion with Seraph 100 Microbind Affinity Filter in patients with severe COVID\u201019 can transiently reduce several inflammatory biomarkers in the blood.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.14137","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T06:49:46Z","timestamp":1715582986000},"page":"802-809","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of a biomimetic pathogen adsorbing device on inflammatory biomarkers in COVID\u201019 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