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Bone and mineral disorders are a common complication among patients with CKD resulting in a poor life quality, high fracture risk, increased morbidity and cardiovascular mortality. According to Kidney Disease: Improving Global Outcomes, renal osteodystrophy refers to changes in bone morphology found in bone biopsy, whereas CKD\u2010mineral and bone disorder (CKD\u2010MBD) defines a complex of disturbances including biochemical and hormonal alterations, disorders of bone and mineral metabolism and extraskeletal calcification. As a result, the management of CKD\u2010MBD should focus on the aforementioned parameters, including the treatment of hyperphosphatemia, hypocalcemia, abnormal PTH and vitamin D levels. Regarding the bone fragility fractures, osteoporosis and renal osteodystrophy, which constitute the bone component of CKD\u2010MBD, anti\u2010osteoporotic agents constitute the mainstay of treatment. However, a thorough elucidation of the CKD\u2010MBD pathogenesis is crucial for the ideal personalized treatment approach. In this paper, we review the pathology and management of CKD\u2010MBD based on the current literature with special attention to recent advances.<\/jats:p>","DOI":"10.1111\/1744-9987.14177","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T05:59:36Z","timestamp":1718863176000},"page":"671-689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Current therapeutic approach of chronic kidney disease\u2010mineral and bone disorder"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3913-1254","authenticated-orcid":false,"given":"Maria","family":"Zaimi","sequence":"first","affiliation":[{"name":"National and Kapodistrian University of Athens, Aretaieio Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirini","family":"Grapsa","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens, Aretaieio Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Stephenson Gehman GKHA. 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