{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:26:40Z","timestamp":1747182400249,"version":"3.40.5"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Peritoneal fibrosis (PF) is a major, persistent complication of prolonged peritoneal dialysis that eventually leads to peritoneal ultrafiltration failure and termination of peritoneal dialysis. Prolonged exposure to high glucose concentrations, degradation products, uremic toxins, and episodes of peritonitis can cause some changes in the peritoneal membrane, resulting in intraperitoneal inflammation and PF, leading to failure of ultrafiltration and dialysis. CA\u2010125 can be used as a biomarker of peritoneal mesothelial cell count in the peritoneal dialysate and for monitoring cell count in PD patients. Hypoxia\u2010inducible factor 1\u2010alpha (HIF\u20101\u03b1) has been reported to cause PF, but has not been reported to be associated with changes in peritoneal structure. We hypothesized that peritoneal adequacy can be followed using HIF\u20101\u03b1 and CA\u2010125 values. In the present study, therefore, we investigated the relationship between HIF\u20101\u03b1 and CA\u2010125 levels and parietal membrane permeability changes in PD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010five patients were included in the study. Peritoneal permeability was constant in 20 of these, while peritoneal permeability increased in 11 and decreased in 14. The HIF\u20101\u03b1 value from the blood samples of the patients and the CA\u2010125 measurement from the peritoneal fluids were measured. The relationship between peritoneal variability and CA\u2010125 and HIF levels after follow\u2010up was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We compared serum HIF\u20101\u03b1 and peritoneal fluid CA\u2010125 levels in the three groups receiving peritoneal dialysis treatment. HIF\u20101\u03b1 levels increased with peritoneal permeability changes, while CA\u2010125 levels decreased. In patients with high to low permeability changes, HIF\u20101\u03b1 levels were higher compared to those with stable or low to high changes, which was statistically significant. Conversely, CA\u2010125 levels significantly decreased in patients whose peritoneal permeability changed from high to low, compared to the other two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Changes in peritoneal structure can be followed with biomarkers. It has been shown that CA\u2010125 and HIF\u20101\u03b1 levels can guide the changes in the peritoneal membrane. This can be useful in the monitoring of peritoneal dialysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.14206","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T05:28:14Z","timestamp":1725514094000},"page":"269-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The relationship between changes in peritoneal permeability with <scp>CA\u2010125<\/scp> and <scp>HIF\u20101\u03b1<\/scp>"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1159-5818","authenticated-orcid":false,"given":"Sumeyra","family":"Koyuncu","sequence":"first","affiliation":[{"name":"Department of Nephrology Kayseri Education and Research Hospital  Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilal","family":"Sipahio\u011flu","sequence":"additional","affiliation":[{"name":"Department of \u0130ntensive Care Unit Kayseri Education and Research Hospital  Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cigdem","family":"Karakukcu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Erciyes Medical Faculty  Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamze","family":"\u0130\u00e7a\u00e7an","sequence":"additional","affiliation":[{"name":"Department of Nephrology Izmir City Hospital  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazmiye Serap","family":"Bi\u00e7er","sequence":"additional","affiliation":[{"name":"Department of Nephrology Erciyes Medical Faculty  Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Kocyigit","sequence":"additional","affiliation":[{"name":"Department of Nephrology Erciyes Medical Faculty  Kayseri 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