{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:40:08Z","timestamp":1791247208574,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T00:00:00Z","timestamp":1731110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T00:00:00Z","timestamp":1731110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903684"],"award-info":[{"award-number":["81903684"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["021414380498"],"award-info":[{"award-number":["021414380498"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2026,10]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n The connection between peritoneal function and gut microbiota in peritoneal fibrosis (PF) patients remains uncertain.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Peritoneal equilibration test (\n PET<\/jats:styled-content>\n ) was employed to evaluate peritoneal function in patients with peritoneal fibrosis (\n PF<\/jats:styled-content>\n ).\n 16S rRNA<\/jats:styled-content>\n sequencing was used to analyze the gut flora in incident peritoneal dialysis (\n PD<\/jats:styled-content>\n ) and\n PF<\/jats:styled-content>\n groups, identifying differential microbial communities. Spearman's correlation analysis, conducted using\n SPSS<\/jats:styled-content>\n 26.0, was employed to explore the microbial associations with\n PF<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In the PF group, the PET showed a 4\u2010h dialysate\u2010to\u2010plasma creatinine ratio (D\/PCr) ratio of 0.62\u2009\u00b1\u20091.01 and a 4\u2010h ultrafiltration (UF) volume of 41.73\u2009\u00b1\u200976.71\u2009mL with a 2.5% glucose dwell. The alpha diversity between the PD and PF groups did not exhibit a significant difference. The PD and PF groups were predominantly composed of\n Firmicutes<\/jats:italic>\n ,\n Tenericutes<\/jats:italic>\n , and\n Ignavibacteriae<\/jats:italic>\n . Linear discriminant analysis effect size (LEfse) analysis indicates that the\n Firmicutes<\/jats:italic>\n ,\n Lactobacillales<\/jats:italic>\n , and\n Bacilli<\/jats:italic>\n were significantly enriched in the PD group, whereas\n Lachnospiraceae<\/jats:italic>\n ,\n Phenylobacterium<\/jats:italic>\n , and\n Caulobacteraceae<\/jats:italic>\n were enriched among the PF group. The functional prediction of gut microbiota genes revealed variations in metabolic pathways related to lipid transport, energy metabolism, and post\u2010translational protein modifications between the two cohorts. In the PF group,\n Ignavibacteriae<\/jats:italic>\n and\n Bdellovibrio<\/jats:italic>\n correlated positively with the 4\u2010h D\/PCr ratio (\n p<\/jats:italic>\n <0.05), while\n Prevotella<\/jats:italic>\n negatively correlated with the 4\u2010h UF from 2.5% glucose dwell (\n p<\/jats:italic>\n <0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The intestinal microbiota of patients newly initiated on peritoneal dialysis significantly differs from that of those with long\u2010term peritoneal dialysis complicated by peritoneal fibrosis, with the latter's peritoneal function potentially linked to\n Prevotella<\/jats:italic>\n ,\n Ignavibacteriae<\/jats:italic>\n , and\n Bdellovibrio<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1744-9987.14226","type":"journal-article","created":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T05:14:11Z","timestamp":1731129251000},"page":"658-668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Comparative analysis of gut microbiota in incident and prevalent peritoneal dialysis patients with peritoneal fibrosis, correlations with\n peritoneal equilibration test<\/scp>\n data in the peritoneal fibrosis cohort"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7110-5926","authenticated-orcid":false,"given":"Jiangqing","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Nanjing Drum Tower Hospital, School of Basic Medicine and Clinical Pharmacy China Pharmaceutical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine Nanjing China"},{"name":"Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jizhong","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Nanjing Drum Tower Hospital, School of Basic Medicine and Clinical Pharmacy China Pharmaceutical University Nanjing China"},{"name":"Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing University Nanjing China"},{"name":"Hunan Provincial Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, the \u201cDouble\u2010First Class\u201d Application Characteristic Discipline of Hunan Province (Pharmaceutical Science) Changsha Medical University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(16)00071-1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60033-6"},{"issue":"12","key":"e_1_2_10_4_1","first-page":"1076","article-title":"Project group of \u201cWhite paper on the status of peritoneal dialysis management in China\u201d. 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