{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:17:00Z","timestamp":1788445020468,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Secondary hyperparathyroidism (sHPT) is a common complication in patients with chronic kidney disease (CKD). Recently, etelcalcetide (EC), an intravenous calcimimetic, has been introduced as a treatment. We evaluated the efficacy of EC in treating sHPT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a multicenter, observational, retrospective study involving hemodialysis patients with sHPT, treated for at least 3\u2009months with EC. We analyzed baseline and follow\u2010up values of intact parathyroid hormone (iPTH), calcium (Ca), phosphate (P), and alkaline phosphatase (ALP). Age, sex, time on dialysis, dialysate calcium concentration, and use of active vitamin D and phosphate binders were also recorded. Patients were divided into those receiving EC as de novo or after at least 3\u2009months of cinacalcet treatment, and according to sHPT severity: PTH &lt;1000 and &gt;1000\u2009pg\/mL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 196 patients. Mean age was 52\u2009\u00b1\u200915\u2009years; 52.3% were male. Median time on hemodialysis was 46.5 (20\u201372) months. Significant reductions were observed in baseline iPTH (1053\u2009pg\/mL), Ca (8.7\u2009mg\/dL), and P (5.7\u2009mg\/dL) over 2\u2009years (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), while ALP levels remained stable. iPTH reduction &gt;30% was achieved in 37.5%, 64%, 66.7%, and 62.5% of patients at 3, 6, 12, and 24\u2009months, respectively. EC was administered as initial treatment in 53% of patients, while 47% were switched from cinacalcet. Significantly iPTH reduction was observed in both groups. Greater reductions were noted in patients with initial PTH &gt;1000\u2009pg\/mL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009). Two patients discontinued due to severe hypocalcemia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EC effectively lowered iPTH and P levels, with a sustained effect over 2\u2009years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1744-9987.14230","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T21:33:12Z","timestamp":1731965592000},"page":"669-675","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Real world evaluation of etelcalcetide in the treatment of secondary hyperparathyroidism in hemodialysis patients in Argentina"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1238-9127","authenticated-orcid":false,"given":"Daniela","family":"Wojtowicz","sequence":"first","affiliation":[{"name":"Hospital El Cruce  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2579-9640","authenticated-orcid":false,"given":"Gustavo","family":"Laham","sequence":"additional","affiliation":[{"name":"CEMIC  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8172-9586","authenticated-orcid":false,"given":"Mariano","family":"Forrester","sequence":"additional","affiliation":[{"name":"Hospital Brit\u00e1nico  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6557-9012","authenticated-orcid":false,"given":"Elisa","family":"del Valle","sequence":"additional","affiliation":[{"name":"Instituto de Diagnostico e Investigaciones Metab\u00f3licas (IDIM)  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7343-5099","authenticated-orcid":false,"given":"Adriana","family":"Pe\u00f1alba","sequence":"additional","affiliation":[{"name":"Hospital Padilla  Tucum\u00e1n Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0746-8441","authenticated-orcid":false,"given":"Graciela","family":"Filannino","sequence":"additional","affiliation":[{"name":"Hospital Castro Rendon  Neuqu\u00e9n Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2282-0737","authenticated-orcid":false,"given":"Andrea","family":"Sammartino","sequence":"additional","affiliation":[{"name":"Nefra Medical Care  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7351-9078","authenticated-orcid":false,"given":"Cecilia","family":"Mengarelli","sequence":"additional","affiliation":[{"name":"Nefrologia Diaverum  Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5691-4563","authenticated-orcid":false,"given":"Guillermo","family":"Rosa\u2010Diez","sequence":"additional","affiliation":[{"name":"Hospital Italiano de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1243-6568","authenticated-orcid":false,"given":"Armando Luis","family":"Negri","sequence":"additional","affiliation":[{"name":"Instituto de Diagnostico e Investigaciones Metab\u00f3licas (IDIM)  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"S1","article-title":"KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease\u2010Mineral and Bone Disorder (CKD\u2010MBD)","volume":"76","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD\u2010MBD Work Group","year":"2009","journal-title":"Kidney Int Suppl"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.04.006"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001514"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq219"},{"issue":"4","key":"e_1_2_7_6_1","first-page":"295","article-title":"Metabolismo \u00f3seo\u2010mineral en 4620 pacientes prevalentes en hemodi\u00e1lisis cr\u00f3nica en Argentina","volume":"40","author":"Del Valle EE","year":"2020","journal-title":"Rev Nefrol Dial Traspl"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2011.627404"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-019-1355-5"},{"key":"e_1_2_7_9_1","unstructured":"Parsabiv. 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