{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:50:08Z","timestamp":1792702208604,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      To investigate the clinical efficacy and safety of plasma exchange (PE) in the treatment of glucocorticoid\u2010insensitive patients with serum anti\u2010\n                      <jats:italic>N<\/jats:italic>\n                      \u2010methyl\u2010\n                      <jats:sc>d<\/jats:sc>\n                      \u2010aspartate (anti\u2010NMDA) receptor antibody\u2010negative and serum anti\u2010NMDA receptor antibody\u2010positive encephalitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The clinical data of 20 patients with anti\u2010NMDA receptor antibody encephalitis treated between January 2015 and December 2022 were collected. The general information, clinical symptoms, auxiliary examination, treatment (hormone, PE, etc.), adverse reactions, clinical efficacy, and other related data were retrospectively compared and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 8 cases had adverse reactions (9.76%, 8\/82), including 4 cases (4.88%, 4\/82) of allergy and 2 cases (2.44%,2\/82) of thrombocytopenia. In patients with anti\u2010NMDA receptor antibody encephalitis who were not sensitive to glucocorticoids, the effective rate of PE was 80.0% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PE combined with glucocorticoid is more effective than glucocorticoid alone in the treatment of anti\u2010NMDA receptor antibody encephalitis patients with positive or negative anti\u2010NMDA receptor antibodies. Most adverse reactions were mild and easy to manage. It does not cause obvious blood cell loss. PE is a safe and acceptable treatment. However, our study has limitations, and due to the small number of people and the fact that plasmapheresis was performed after glucocorticoid therapy, further prospective clinical studies are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1744-9987.14240","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T03:22:37Z","timestamp":1734405757000},"page":"698-704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["To analyze the efficacy and safety of plasma exchange in the treatment of anti\u2010\n                    <scp>NMDA<\/scp>\n                    receptor encephalitis"],"prefix":"10.1111","volume":"30","author":[{"given":"Jing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nephrology Wuzhou Red Cross Hospital  Wuzhou China"},{"name":"General Internal Medicine Guangxi Medical University Cancer Hospital  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binghai","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nephrology First Affiliated Hospital of Guangxi Medical University  Nanning China"},{"name":"Department of Nephrology Yulin First People's Hospital  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifang","family":"Lao","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Guangxi Medical University Cancer Hospital  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longtao","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Guangxi Medical University Cancer Hospital  Nanning 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plasma exchange in rheumatic diseases: a university hospital experience","volume":"57","author":"C\u00f3rdoba JP","year":"2017","journal-title":"Rev Bras Reumatol"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12629"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4299791"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21363"},{"issue":"10","key":"e_1_2_11_16_1","first-page":"18927","article-title":"Clinical analysis on anti\u2010N\u2010methyl\u2010d\u2010aspartate receptor encephalitis cases: Chinese experience","volume":"8","author":"Huang X","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7796833"},{"issue":"2","key":"e_1_2_11_18_1","first-page":"207","article-title":"Apheresis registry in France: indications, techniques and complications","volume":"18","author":"Korach JM","year":"2014","journal-title":"Ther 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