{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:08:55Z","timestamp":1764688135542,"version":"3.40.4"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The relationship between time\u2010averaged serum uric acid (TA\u2010SUA) levels and prognosis in peritoneal dialysis (PD) patients are rarely discussed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort study. PD patients recruited from January 1, 2011, to December 31, 2020, were included. Baseline and follow\u2010up uric acid levels over 1 year were collected to calculate time\u2010averaged serum uric acid (TA\u2010SUA) levels. Patients were divided into four groups based on TA\u2010SUA quartiles: Q1 (&lt;5.1\u2009mg\/dl), Q2 (5.1\u20135.8\u2009mg\/dl), Q3 (5.8\u20136.8\u2009mg\/dl), and Q4 (&gt;6.8\u2009mg\/dl).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total 487 PD patients with a mean age of 52.0\u2009\u00b1\u200914.2 were enrolled, including114 (23.4%) diabetes. Q1 (<jats:italic>n<\/jats:italic>\u2009=\u2009121, 24.8%), Q2 (<jats:italic>n<\/jats:italic>\u2009=\u2009118, 24.2%), Q3 (<jats:italic>n<\/jats:italic>\u2009=\u2009125, 25.7%), and Q4 (<jats:italic>n<\/jats:italic>\u2009=\u2009123, 25.3%). The Q1 group exhibited characteristics of increased age, malnutrition, and a higher prevalence of diabetes. During the 48.1\u2009months follow\u2010up time, 197 (35.8%) died, 109 (55.3%) cardiovascular disease (CVD), 38 (19.3%) infections. Kaplan\u2013Meier analysis revealed that both all\u2010cause mortality and cardiovascular mortality were significantly higher in the Q1 and Q4 groups (log\u2010rank\u2009=\u200924.373, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). COX regression analysis showed that decreased TA\u2010SUA level was an independent risk factor for all\u2010cause mortality in PD patients after adjustment for confounding factors. Each 1\u2009mg\/dl decrease in TA\u2010SUA level was associated with a 23.46% increase in all\u2010cause mortality (HR\u2009=\u20090.81, 95% CI, 0.71\u20130.94; <jats:italic>p<\/jats:italic>\u2009=\u20090.004*). Lower serum albumin level was associated with increased all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PD patients with lower TA\u2010SUA were older and had a higher proportion of diabetes and malnourishment than those with higher TA\u2010SUA. Long\u2010term exposure to low TA\u2010SUA levels was an independent predictor of all\u2010cause and cardiovascular mortality in PD patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.14252","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T03:45:01Z","timestamp":1738727101000},"page":"479-490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lower time\u2010averaged serum uric acid was associated with increased mortality in peritoneal dialysis patients"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7358-8781","authenticated-orcid":false,"given":"Lu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nephrology General Hospital of Ningxia Medical University  Yinchuan Ningxia China"},{"name":"Ningxia Nephrology Disease Clinical Research Center  Yinchuan Ningxia 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School of Ningxia Medical University General Hospital of Ningxia  Yinchuan Ningxia China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenlong","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Nephrology General Hospital of Ningxia Medical University  Yinchuan Ningxia China"},{"name":"Ningxia Nephrology Disease Clinical Research Center  Yinchuan Ningxia China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Nephrology General Hospital of Ningxia Medical University  Yinchuan Ningxia China"},{"name":"Ningxia Nephrology Disease Clinical Research Center  Yinchuan Ningxia China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menghua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology General Hospital of Ningxia Medical University  Yinchuan Ningxia China"},{"name":"Ningxia Nephrology Disease Clinical Research Center  Yinchuan Ningxia China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Nephrology General Hospital of Ningxia Medical University  Yinchuan Ningxia China"},{"name":"Ningxia Nephrology Disease Clinical Research Center  Yinchuan Ningxia 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