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China has been ranked first in the world for patients undergoing hemodialysis (HD) and peritoneal dialysis (PD) with approximately one million patients across the country. Due to the loss of kidney function caused by CKD, the kidneys tend to lose their ability to excrete uric acid (UA) out of the body; therefore, most patients undergoing dialysis are complicated with hyperuricemia (HUA). HUA is an abnormal disease of purine metabolism, and it's considered a chronic disease. More than 90% of patients suffering from HUA will not show any symptoms on physical examination. According to statistics, if high serum UA is left untreated, 55% of patients will develop severe problems due to the purine crystallization in the body, and the kidneys are the most affected organs by HUA causing renal insufficiency that can promote end\u2010stage kidney disease (ESKD) by activating the renin\u2010angiotensin system (RAS), which will lead to inflammation, arteriosclerosis, cardiovascular diseases (CVD), and other diseases. Lifestyle modifications and pharmacological interventions are the first primary choice for lowering UA, although dialysis will tend to reduce the high UA levels in the blood, drugs are also necessary. This review will summarize the mechanisms and metabolism of UA, the relationship between HUA and ESKD progression, HUA and inflammation, HUA and CVD, and pharmacological treatment of HUA.<\/jats:p>","DOI":"10.1111\/1744-9987.70000","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T22:16:16Z","timestamp":1739916976000},"page":"817-838","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The role of hyperuricemia in the progression of end\u2010stage kidney disease and its molecular prospective in inflammation and cardiovascular diseases: A general review"],"prefix":"10.1111","volume":"29","author":[{"given":"Yousuf Abdulkarim","family":"Waheed","sequence":"first","affiliation":[{"name":"Department of Nephrology Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Clinical Research Center for Kidney Disease Xuzhou Medical University  Xuzhou 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