{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T15:59:27Z","timestamp":1772639967884,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Phosphate binders (PBs) are commonly prescribed to reduce serum phosphate levels. This study examined the association between the PB pill burden and cardiovascular events in hemodialysis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study included 395 patients undergoing hemodialysis between August 2018 and November 2023 at a single facility in Japan. Statistical analyses were conducted using baseline, time\u2010averaged, and time\u2010dependent Cox proportional hazard models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 395 included patients, cardiovascular events occurred in 121 patients (30.6%). The patients were categorized into tertiles based on their daily PB pill intake: T1 (&lt;4 pills\/day), T2 (4\u20138 pills\/day), and T3 (\u22659 pills\/day). T3 was associated with increased cardiovascular risk (vs. T1 hazard ratio [HR]\u2009=\u20091.51, <jats:italic>p<\/jats:italic>\u2009=\u20090.064; vs. T2 HR\u2009=\u20092.06, <jats:italic>p<\/jats:italic>\u2009=\u20090.005). Similar results were obtained for the time\u2010averaged and time\u2010dependent models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A high PB pill burden (\u22659\/day) is associated with increased cardiovascular risk in patients undergoing hemodialysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.70004","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T09:35:59Z","timestamp":1741599359000},"page":"333-344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Phosphate binder pill burden and cardiovascular events in patients undergoing hemodialysis"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2293-0132","authenticated-orcid":false,"given":"Kiryu","family":"Yoshida","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Showa University Northern Yokohama Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Saito","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Showa University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Kato","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Showa University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Takezaki","sequence":"additional","affiliation":[{"name":"Saiyu Clinic  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Kato","sequence":"additional","affiliation":[{"name":"Saiyu Clinic  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6117-8414","authenticated-orcid":false,"given":"Masahide","family":"Mizobuchi","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Showa University Fujigaoka Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0046-5575","authenticated-orcid":false,"given":"Hiroaki","family":"Ogata","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Showa University Northern Yokohama Hospital  Yokohama Japan"},{"name":"Department of Medical Education Showa University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3832-701X","authenticated-orcid":false,"given":"Fumihiko","family":"Koiwa","sequence":"additional","affiliation":[{"name":"Division of 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