{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T08:06:43Z","timestamp":1774771603411,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The aim of this study was to determine the relationship between albuminuria and neutrophil\u2010to\u2010lymphocyte ratio (NLR), platelet\u2010to\u2010lymphocyte ratio (PLR) and monocyte\u2010to\u2010high density lipoprotein\u2010cholesterol ratio (MHR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with type 2 diabetes mellitus diagnosis, aged over 18, had estimated glomerular filtration rate (eGFR) \u226560\u2009mL\/dk\/1.73\u2009m<jats:sup>2<\/jats:sup> included. Patients were divided into groups according to ACR values: &lt;30\u2009mg\/g (group 1), 30\u2013300\u2009mg\/g (group 2) and &gt;300\u2009mg\/g (group 3). We examined whether there was a significant difference in NLR, PLR, and MHR among the three groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 360 patients were included in the study. NLR was significantly higher in group 3 than in group 1 (<jats:italic>p<\/jats:italic>\u2009=\u20090.016). There was no significant difference in PLR or MHR among the three groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.312 and <jats:italic>p<\/jats:italic>\u2009=\u20090.687, respectively). A significant difference was detected in NLR in comparison between the groups with and without diabetic nephropathy, but there was no significant difference in PLR or MHR (<jats:italic>p<\/jats:italic>\u2009=\u20090.028; <jats:italic>p<\/jats:italic>\u2009=\u20090.950 and <jats:italic>p<\/jats:italic>\u2009=\u20090.389, respectively). NLR correlated with creatinine and ACR (<jats:italic>r<\/jats:italic>: 0.166, <jats:italic>p<\/jats:italic>\u2009=\u20090.002; <jats:italic>r<\/jats:italic>: 0.144, <jats:italic>p<\/jats:italic>\u2009=\u20090.006, respectively). MHR correlated positively with creatinine (<jats:italic>r<\/jats:italic>: 0.25.3, <jats:italic>p<\/jats:italic>\u2009=\u20090.016, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NLR was significantly higher in the diabetic nephropathy group than in the non\u2010diabetic nephropathy group. This may suggest that NLR can be used as a prognostic marker in diabetic nephropathy. Although there was no significant relationship between MHR and albuminuria, MHR positively correlated with creatinine and negatively correlated with eGFR. Therefore, MHR may be useful in monitoring the development and progression of chronic kidney disease in diabetic patients rather than in the early stages. However, further studies are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.70008","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T14:54:58Z","timestamp":1742741698000},"page":"428-436","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of neutrophil\u2013lymphocyte ratio, platelet\u2013lymphocyte ratio and monocyte\u2010to\u2010high\u2010density lipoprotein ratio with diabetic nephropathy"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6976-0724","authenticated-orcid":false,"given":"Gulru Birce","family":"Sonmezoz","sequence":"first","affiliation":[{"name":"Taksim Training and Research Hospital Department of Internal Medicine  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murvet","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Bakirkoy Dr. Sadi Konuk Training and 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