{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:14:33Z","timestamp":1794323673568,"version":"4.9.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2023A04J2185"],"award-info":[{"award-number":["2023A04J2185"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hemodialysis (HD) is significantly affected by cardiovascular diseases (CVD), immune dysfunction, and inflammation, involving interactions of inflammatory cells and lipid metabolism disorders. This study aimed to investigate the association between the complex indices and all\u2010cause and cardiovascular mortality, as well as to compare the prognostic efficacy of the complex indices in the prediction of all\u2010cause and cardiovascular mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study analyzed data from 1236 patients undergoing HD in four blood purification centers in China. It investigated the association between complex indices including the pan\u2010immune\u2010inflammation value (PIV), systemic immune\u2010inflammation index (SII), systemic inflammation response index (SIRI), monocyte\u2010to\u2010high\u2010density lipoprotein\u2010cholesterol ratio (MHR), and neutrophil\u2010to\u2010lymphocyte ratio (NLR) with all\u2010cause and cardiovascular mortality. ROC curve analysis was employed to evaluate prognostic efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>It was found that there were significantly positive correlations between the investigated indices (PIV, SIRI, SII, MHR, and NLR) and both all\u2010cause and cardiovascular mortality in HD patients. MHR emerged as a stronger independent risk factor in mortality compared to the other indices, both with all\u2010cause mortality (OR 8.80; 95%CI 1.22\u201363.49) and cardiovascular mortality (OR 191.65; 95%CI 43.52\u2013843.88). PIV showed superior prognostic efficacy for all\u2010cause (AUC 0.93; 95%CI 0.92\u20130.95) and cardiovascular mortality (AUC 0.93; 95%CI 0.91\u20130.95).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Complex indices of PIV, SIRI, SII, MHR, and NLR are significantly associated with mortality in patients under hemodialysis. MHR, as a potent independent predictor, and PIV, with its high diagnostic efficacy, played a critical role in systemic inflammation and altered lipid metabolism over the risk of mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.70010","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T19:34:02Z","timestamp":1743017642000},"page":"345-356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association between complex indices of blood cell types and lipid levels with all\u2010cause, cardiovascular mortality in hemodialysis patients: A multicenter retrospective study"],"prefix":"10.1111","volume":"29","author":[{"given":"Minjie","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Nephrology, the First Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 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