{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:21:53Z","timestamp":1753878113643,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T00:00:00Z","timestamp":1744502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Metastatic castration\u2010resistant prostate cancer (mCRPC) has a poor prognosis. This study evaluated the safety, immune responses, and clinical outcomes of Wilms' tumor 1 (WT1) peptide\u2010loaded dendritic cell (DC) vaccination combined with hormone or chemotherapeutic agents in mCRPC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>WT1 peptide\u2010loaded mature DCs were administered intradermally and the adjuvant OK\u2010432 every 2\u20134\u2009weeks. WT1\u2010specific immune responses were assayed using ELISpot, HLA\u2010tetramer, and CD107a assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Vaccination was well tolerated with no severe adverse events. WT1\u2010specific immune responses were significantly enhanced in patients with stable disease (SD), along with reduced regulatory T cells. A PSA reduction of &gt;50% was achieved in 35.7% of patients. Median overall survival (mOS) was 28.5\u2009months, exceeding the Halabi nomogram's estimate (19.0\u2009months). Patients with WT1\u2010specific immune responses exhibited significantly longer mOS, suggesting a link between WT1\u2010specific immunity and favorable outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This immunotherapy approach shows promise for improving survival in mCRPC patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.70016","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T04:55:11Z","timestamp":1744606511000},"page":"568-576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combined immunotherapy employing Wilms' tumor 1 peptide\u2010pulsed dendritic cells and hormone or chemotherapeutic agents in patients with metastatic castration resistant prostate 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