{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:35:59Z","timestamp":1780914959003,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>This single\u2010center retrospective study investigated the clinical effects of combination therapy involving continuous renal replacement therapy (CRRT) and continuous intravenous sodium infusion therapy (cIVNa) in critically ill patients with prerenal acute kidney injury (AKI) who were expected to experience insufficient plasma refilling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The clinical data of 92 patients were analyzed. Clinical data from the control (CRRT, <jats:italic>n<\/jats:italic>\u2009=\u200949) and intervention (CRRT\u2009+\u2009cIVNa, <jats:italic>n<\/jats:italic>\u2009=\u200943) groups were compared statistically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Combination therapy increased blood pressure and urine volume, while reducing hypotension events, indicating hemodynamic stabilization. Furthermore, it significantly improved the 90\u2010day survival rate (61.9% vs. 38.8%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), 60\u2010day and 90\u2010day survival rates without RRT (59.5% vs. 28.6%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01; 54.8% vs. 26.5%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01, respectively), survival discharge rate from intensive care unit, CRRT withdrawal rate, and renal replacement therapy withdrawal rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Combination therapy with continuous renal replacement therapy and continuous intravenous sodium infusion therapy may be a useful treatment option for critically ill patients with prerenal acute kidney injury who require continuous renal replacement therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.70021","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T01:32:21Z","timestamp":1744767141000},"page":"543-556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical effects of combination therapy with continuous renal replacement therapy and continuous intravenous sodium infusion therapy"],"prefix":"10.1111","volume":"29","author":[{"given":"Akinori","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Nephrology Shinshu University School of Medicine  Matsumoto Nagano Japan"},{"name":"Intensive Care Unit Shinshu University Hospital  Matsumoto Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuyoshi","family":"Mita","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Shinshu University Hospital  Matsumoto Nagano 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