{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:24:43Z","timestamp":1753878283887,"version":"3.41.2"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>To investigate the role of Huaiqihuang granule in the inhibition and immune regulation of peritoneal fibrosis in peritoneal dialysis rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Peritoneal fibrosis rat models were established and subsequently assigned to five groups: a normal group (Group A); a model group (Group B); a low\u2010concentration treatment group (Group C); a medium\u2010concentration treatment group (Group D); and a high\u2010concentration treatment group (Group E). The normal rats served as the control group (Group A). All rats underwent intragastric administration of Huaiqihuang granules for a duration of 21\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Peritoneal histopathological staining showed that group B rats had the highest degree of peritoneal fibrosis. In the intervention group, the degree of peritoneal fibrosis decreased with the increase of concentration of Huaiqihuang granule with a significant difference (<jats:italic>p<\/jats:italic> &lt;0.05). Immunohistochemical analysis showed that the expression of TGF\u2010<jats:italic>\u03b2<\/jats:italic>1, TNF\u2010<jats:italic>\u03b1<\/jats:italic>, and <jats:italic>\u03b1<\/jats:italic>\u2010SMA in rat peritoneal tissue was higher in group B than in group E (<jats:italic>p<\/jats:italic>&lt;\u20090.05). Polymerase Chain Reaction (PCR) detection of mRNA expression of TGF\u20101 and fibronectin in rat peritoneal tissues: group B&gt;group C&gt;group D&gt;group E&gt;group A (<jats:italic>p<\/jats:italic>&lt;0.05). The macrophage phagocytosis function, the levels of CD3+, CD4+, CD8+ T cells, and the CD4+\/CD8+ ratio in peripheral blood were lowest in group B compared to groups C, D, and E (<jats:italic>p<\/jats:italic> &lt; 0.05). In contrast, the levels of IL\u20102, IL\u20106, TGF\u2010\u03b21, and TNF\u2010\u03b1 were highest in group B (<jats:italic>p<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It is speculated that Huaiqihuang granule may be used clinically as effective drugs to improve peritoneal fibrosis and regulate immune function in peritoneal dialysis patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.70031","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T11:44:59Z","timestamp":1747223099000},"page":"653-661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Influence of Huaiqihuang granule on peritoneal fibrosis induced by peritoneal dialysis: A study based on rat model"],"prefix":"10.1111","volume":"29","author":[{"given":"Lin","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Nephrology The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology  Wuhan Hubei China"},{"name":"Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology  Wuhan Hubei China"},{"name":"Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongxia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of 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