{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T18:12:02Z","timestamp":1757614322028,"version":"3.44.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008645","name":"Terumo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008645","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The efficacy of peritoneal lavage monotherapy using PD solution for severe peritonitis remains unproven.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated the effects of 3\u2010times and 6\u2010times lavage using low GDP neutral PD solution on a Methicillin\u2010sensitive <jats:styled-content style=\"fixed-case\">\n<jats:italic>Staphylococcus aureus<\/jats:italic>\n<\/jats:styled-content> (MSSA) lethal peritonitis model rats without antibiotic use. Changes in effluent viable bacteria numbers dependent on lavage frequency were determined in a further 10 rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the lethal peritonitis model without lavage, both 3\u2010times and 6\u2010times lavage significantly reduced 24\u2010h mortality, effluent FDP and creatinine concentrations. Furthermore, 6\u2010times lavage significantly prevented the rough fur development, intraabdominal adhesion, and pus formation which developed in both the 0\u2010times and 3\u2010times lavage groups. The effluent viable bacterial counts showed significant step\u2010ladder decreases with an increasing number of the lavages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We demonstrated for the first time that lavage monotherapy using PD solution reduces mortality and severity in a lethal peritonitis model by rapidly eliminating bacteria without antibiotic use.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1744-9987.70061","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:34:36Z","timestamp":1752107676000},"page":"752-759","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Peritoneal Lavage With Low <scp>GDP<\/scp> Neutral <scp>pH PD<\/scp> Solution Reduces Mortality and Severity in a Lethal Peritonitis Model"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3583-5975","authenticated-orcid":false,"given":"Masato","family":"Ikeda","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension The Jikei University Kashiwa Hospital  Chiba Japan"},{"name":"Division of Nephrology and Hypertension The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1918-0390","authenticated-orcid":false,"given":"Kotaro","family":"Haruhara","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension The Jikei University Kashiwa Hospital  Chiba Japan"},{"name":"Division of Nephrology and Hypertension The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5602-8104","authenticated-orcid":false,"given":"Yukio","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Evaluation Center Terumo Corporation  Ashigarakami Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risa","family":"Kusanagi","sequence":"additional","affiliation":[{"name":"Evaluation Center Terumo Corporation  Ashigarakami Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri","family":"Sakamaki","sequence":"additional","affiliation":[{"name":"Evaluation Center Terumo Corporation  Ashigarakami Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitomi","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Evaluation Center Terumo Corporation  Ashigarakami Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1838-7998","authenticated-orcid":false,"given":"Takashi","family":"Yokoo","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00104\u2010010\u20102015\u20102"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2017.10.017"},{"issue":"8","key":"e_1_2_10_4_1","first-page":"1064","article-title":"Effects of Infectious Complications on Patients' Survival in Peritoneal Dialysis","volume":"17","author":"Sinangil A.","year":"2013","journal-title":"European Review for Medical and Pharmacological Sciences"},{"issue":"10","key":"e_1_2_10_5_1","first-page":"E1","article-title":"Septic Peritonitis","volume":"32","author":"Culp W. 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