{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T06:56:57Z","timestamp":1773039417335,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study explores immune responses to SARS\u2010CoV\u20102 vaccination among dialysis patients and kidney transplant recipients (KTRs). Dialysis patients and KTRs often exhibit lower seroconversion rates, particularly the latter, due to immunosuppressive therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The prospective study was conducted at the University Malaya Medical Centre (UMMC), involving 62 dialysis patients and 49 KTRs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Dialysis patients exhibited high seroconversion (97.8%) and T\u2010cell response (77.4%). In contrast, KTRs had poor seroconversion (59.2%) and a weak T\u2010cell response (44.9%) after a third dose. Furthermore, 32.7% of KTRs were non\u2010reactive in both antibody and T\u2010cell responses. A moderate correlation was found between antibody levels and T\u2010cell responses in KTRs (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.305). Among dialysis patients, lower BMI was significantly associated with reduced seroconversion, while longer dialysis duration and the presence of hypertension were positively associated with antibody response. Other clinical factors, including age, gender, diabetes, and prior COVID\u201019 infection, showed no significant association.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings suggest dialysis patients respond better to vaccination, while KTRs experience impaired immune responses. Within dialysis patients, BMI, dialysis duration, and hypertension influenced antibody response. Monitoring post\u2010vaccination immune responses in KTRs may help identify non\u2010responders, who could benefit from alternative vaccination strategies or adjustments in immunosuppressive therapy. This study was approved by the University Malaya Medical Centre Medical Research Ethics Committee (UMMC\u2010MREC), Approval No: 202131\u20109888.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1744-9987.70066","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T08:14:31Z","timestamp":1752480871000},"page":"839-849","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploring the Immune Response to\n                    <scp>COVID<\/scp>\n                    \u201019 Vaccines in Dialysis and Transplant Patients"],"prefix":"10.1111","volume":"29","author":[{"given":"Hui Wen","family":"You","sequence":"first","affiliation":[{"name":"Faculty of Medicine Universiti Malaya  Kuala Lumpur Wilayah Persekutuan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Kun","family":"Lim","sequence":"additional","affiliation":[{"name":"Head of Renal Division University Malaya Medical Center, Department of Medicine, Faculty of Medicine Universiti Malaya  Kuala Lumpur Wilayah Persekutuan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boon Hong","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Faculty of Medicine Universiti Malaya  Kuala Lumpur Wilayah Persekutuan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shian Feng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Nephrology Universiti Malaya  Kuala Lumpur Wilayah Persekutuan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reena","family":"Rajasuriar","sequence":"additional","affiliation":[{"name":"Department of Medicine Universiti Malaya  Kuala Lumpur Wilayah Persekutuan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3109-8998","authenticated-orcid":false,"given":"Hui Wei","family":"You","sequence":"additional","affiliation":[{"name":"School of Economics and Management Xiamen University Malaysia  Sepang Selangor Malaysia"},{"name":"Faculty of Business UNITAR International University  Petaling Jaya Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.09.006"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaa271"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2521-4"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2021.100178"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021040480"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03500321"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16607"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034577"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2035389"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm0829"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-027599"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm3425"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01377-8"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003983"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.01.007"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac557"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2114583"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-19581-y"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqaa155"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2021.114295"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI150175"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.12.006"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.01.015"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004140"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16933"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.7489"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101642"},{"issue":"6","key":"e_1_2_12_29_1","first-page":"527","article-title":"Response Rates to HB Vaccine in CKD Stages 3\u20104 and Hemodialysis Patients","volume":"17","author":"Ghadiani M. 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