{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:20:49Z","timestamp":1773832849334,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Although continuous kidney replacement therapy (CKRT) for acute kidney injury (AKI) management is common, its effect on the outcomes of patients treated with extracorporeal membrane oxygenation (ECMO) for severe coronavirus disease 2019 (COVID\u201019) remains unclear. Therefore, we aimed to investigate the impact of CKRT on the outcomes of these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using a database of patients with severe COVID\u201019 who required venovenous ECMO across three centers in Japan, we assessed demographics, clinical parameters, and in\u2010hospital mortality rates from January 2020 to December 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data of 122 patients treated with ECMO for COVID\u201019 were analyzed. Forty\u2010five patients required CKRT; the in\u2010hospital mortality rate was 28.7%. Multivariate analysis showed age and CKRT were independent risk factors for in\u2010hospital mortality. The in\u2010hospital mortality rate was significantly higher in the CKRT group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CKRT was associated with significantly high in\u2010hospital mortality in patients treated with ECMO for severe COVID\u201019.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1744-9987.70071","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T01:54:39Z","timestamp":1754358879000},"page":"866-870","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Continuous Kidney Replacement Therapy and Outcomes of Severe Coronavirus Disease 2019 Treated With Extracorporeal Membrane Oxygenation"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9972-9402","authenticated-orcid":false,"given":"Yoshito","family":"Izutani","sequence":"first","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, Faculty of Medicine Fukuoka University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0136-4394","authenticated-orcid":false,"given":"Yasumasa","family":"Kawano","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, Faculty of Medicine Fukuoka University  Fukuoka Japan"},{"name":"Department of Emergency and General Medicine Fukuoka University Chikushi Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, Faculty of Medicine Fukuoka University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, Faculty of Medicine Fukuoka University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Muranishi","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, Faculty of Medicine Fukuoka University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kota","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, Faculty of Medicine Fukuoka University  Fukuoka Japan"},{"name":"Department of Critical Care and Emergency Center Nanbu Medical Center and Children's Medical Center  Okinawa Japan"},{"name":"Department of Emergency Medicine Graduate School of Medicine, University of the Ryukyus  Okinawa 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Center Fukuoka University Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineering Center Fukuoka University Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineering Center Fukuoka University Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3410-8101","authenticated-orcid":false,"given":"Jun","family":"Hamaguchi","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Tokyo Metropolitan Tama Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naofumi","family":"Bunya","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Sapporo Medical University  Sapporo Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3272-7680","authenticated-orcid":false,"given":"Ryuichi","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Sapporo Medical University  Sapporo Hokkaido Japan"},{"name":"Division of Intensive Care, Department of Anesthesiology and Intensive Care Medicine Jichi Medical University School of Medicine  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Tokyo Metropolitan Tama Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, Faculty of Medicine Fukuoka University  Fukuoka 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