{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:03:27Z","timestamp":1792692207999,"version":"4.5.0"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>High\u2010dose online HDF compared with hemodialysis reduces all\u2010cause mortality, but increases water consumption. We postulate that the conundrum could be solved by individualizing dialysate flow.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty CKD5D patients undergoing online HDF post\u2010dilution were changed from fixed dialysate flow (500\u2009mL\/min) to individualized dialysate flow, resulting in a dialysate flow that was always 20% higher than the blood flow.\n                      <jats:italic>Kt<\/jats:italic>\n                      \/\n                      <jats:italic>V<\/jats:italic>\n                      <jats:sub>urea<\/jats:sub>\n                      , K\n                      <jats:sup>+<\/jats:sup>\n                      , Phos, and pill burden in one quater pre as well as four quarters after the change were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The practice change resulted in a reduction of the fixed dialysate flow from 500 to 360 (240\u2013383)\u2009mL\/min. Parameters of dialysis adequacy did not change; neither did the medication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An individualization of the dialysate flow saved about 36\u2009L dialysate per session; hence, even in light of 23\u2009L used for online HDF, the net burden on the environment could be reduced. Neither dialysis adequacy nor pill burden was negatively affected.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1744-9987.70072","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T01:28:02Z","timestamp":1754962082000},"page":"885-889","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Smart, Individualized Green Hemodiafiltration \u2010 Effects of Individualized Dialysate Flow Through\n                    <scp>AutoFlow<\/scp>\n                    on Dialysate Consumption and Parameters of Dialysis Adequacy in the Setting of Online Hemodiafiltration"],"prefix":"10.1111","volume":"29","author":[{"given":"Vanessa","family":"David","sequence":"first","affiliation":[{"name":"Medical Clinic V, Nephrology, Rheumatology, and Blood Purification Academic Teaching Hospital Braunschweig  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastian","family":"Au","sequence":"additional","affiliation":[{"name":"Medical Clinic V, Nephrology, Rheumatology, and Blood Purification Academic Teaching Hospital Braunschweig  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten M.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Medical Clinic V, Nephrology, Rheumatology, and Blood Purification Academic Teaching Hospital Braunschweig  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4656-1669","authenticated-orcid":false,"given":"Kijanosh","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Medical Clinic V, Nephrology, Rheumatology, and Blood Purification Academic Teaching Hospital Braunschweig  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8110-9064","authenticated-orcid":false,"given":"Jan T.","family":"Kielstein","sequence":"additional","affiliation":[{"name":"Medical Clinic V, Nephrology, Rheumatology, and Blood Purification Academic Teaching Hospital Braunschweig  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157014"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.04.008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000530439"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfae238"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01859-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.5772\/58878"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/13.12.3118"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2011.01040.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.70004"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000166765"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002750"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfae163"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1744-9987.70072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:21:33Z","timestamp":1765974093000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1744-9987.70072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,11]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/1744-9987.70072"],"URL":"https:\/\/doi.org\/10.1111\/1744-9987.70072","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,11]]},"assertion":[{"value":"2024-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}