{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:41:53Z","timestamp":1787013713723,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lipoprotein apheresis reduces low\u2010density lipoprotein (LDL) cholesterol in high\u2010risk patients, but its effects on plasma ion levels remain unclear. The objective of this study was to systematically evaluate the impact of apheresis on plasma calcium, sodium, potassium, magnesium, and chloride concentrations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Following PRISMA guidelines, we searched MEDLINE\/PubMed, Scopus, and Web of Science to June 2025. Studies reporting pre\u2010 and post\u2010apheresis ion levels with at least two sessions were included. Weighted mean differences (WMD) with 95% confidence intervals (CI) were calculated using fixed\u2010 or random\u2010effects models. Subgroup analyses and meta\u2010regression explored heterogeneity. Publication bias was assessed with Egger's test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twelve studies (10 publications, 328 participants) showed a significant reduction in total calcium after apheresis (WMD\u2009=\u2009\u22120.10\u2009mmol\/L; 95% CI\u2009=\u2009\u22120.15 to \u22120.05;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Effects were stronger with \u2265\u200912\u2009months of treatment and in patients with heart disease. No significant changes were found for sodium, potassium, magnesium, or chloride. Meta\u2010regression identified treatment duration and publication year as sources of heterogeneity for calcium outcomes. No publication bias was detected except potentially for magnesium.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lipoprotein apheresis is associated with modest but significant reductions in plasma calcium, especially in patients with heart disease or prolonged treatment, highlighting the need for electrolyte monitoring. No consistent effects were observed for other plasma ions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1744-9987.70091","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:00:49Z","timestamp":1761660049000},"page":"46-58","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Impact of Lipid Apheresis on Changes of Plasma Ions: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"30","author":[{"given":"Bahman","family":"Razi","sequence":"first","affiliation":[{"name":"Department of Laboratory Sciences and Hematology, School of Allied Medical Science North Khorasan University of Medical Sciences  Bojnurd Iran"},{"name":"Student Research Committee, Faculty of Allied Medical Sciences North Khorasan University of Medical Sciences  Bojnurd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Eslami","sequence":"additional","affiliation":[{"name":"Department of Hematology and Blood Transfusion, Faculty of Medical Sciences Tarbiat Modares University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Hatami","sequence":"additional","affiliation":[{"name":"Department of Hematology and Blood Transfusion, Faculty of Medical Sciences Tarbiat Modares University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Aslani","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Clinical Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasim Sakran","family":"Abass","sequence":"additional","affiliation":[{"name":"Department of Physiology, Biochemistry, and Pharmacology; College of Veterinary Medicine University of Kirkuk  Kirkuk Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tannaz","family":"Jamialahmadi","sequence":"additional","affiliation":[{"name":"Pharmaceutical Research Center Pharmaceutical Technology Institute, Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-1444","authenticated-orcid":false,"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center Pharmaceutical Technology Institute, Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Centre for Research Impact &amp; Outcome, Chitkara College of Pharmacy Chitkara University  Rajpura Punjab India"},{"name":"Applied Biomedical Research Center Basic Sciences Research Institute, Mashhad University of Medical Sciences  Mashhad 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