{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:57:37Z","timestamp":1785455857614,"version":"3.56.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:00:00Z","timestamp":1762646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:00:00Z","timestamp":1762646400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Oxidative stress (OS), inflammation, and lipoprotein dysfunction contribute to the high cardiovascular disease (CVD) risk in chronic kidney disease (CKD) patients undergoing hemodialysis (HD). This study examined whether OS\u2010related biomarkers\u2014myeloperoxidase (MPO), paraoxonase\u20101 (PON1), and homocysteine (HCY)\u2014and their derived ratios (MPO\/PON1, MPO\/HDL\u2010C, PON1\/HDL\u2010C) are associated with cardiovascular risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A case\u2013control study was conducted including 42 HD patients and 42 matched healthy controls. Plasma HCY levels, MPO activity, and PON1 activity were measured, along with lipid profiles. Functional OS ratios were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HD patients showed higher MPO activity and HCY levels and lower PON1 activity compared with controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). MPO\/PON1 and MPO\/HDL\u2010C ratios were significantly elevated before and after dialysis, indicating increased oxidative imbalance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The MPO\/PON1 ratio may represent a novel biomarker of OS and CVD risk in HD patients, supporting the evaluation of HDL functionality for improved risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1744-9987.70094","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:45:03Z","timestamp":1762735503000},"page":"78-84","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oxidative Stress\u2010Related\n                    <scp>HDL<\/scp>\n                    Dysfunction in Hemodialysis: The Clinical Utility of\n                    <scp>MPO<\/scp>\n                    \/\n                    <scp>PON1<\/scp>\n                    and\n                    <scp>MPO<\/scp>\n                    \/\n                    <scp>HDL<\/scp>\n                    \u2010C Ratios in Cardiovascular Risk Assessment"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4195-0884","authenticated-orcid":false,"given":"Elif Azize \u00d6z\u015fahin","family":"Deliba\u015f","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, Department of Nutrition and Dietetics Tokat Gaziosmapasa University  Tokat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1693-1155","authenticated-orcid":false,"given":"Kader","family":"K\u00f6se","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Basic Medical Sciences Erciyes University  Kayseri Turkey"},{"name":"Faculty of Medicine, Department of Medical Biochemistry Erciyes University  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0625-9542","authenticated-orcid":false,"given":"Cevat","family":"Yazici","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Basic Medical Sciences Erciyes University  Kayseri Turkey"},{"name":"Faculty of Medicine, Department of Medical Biochemistry Erciyes University  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0880-3396","authenticated-orcid":false,"given":"B\u00fclent","family":"Tokg\u00f6z","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Internal Medical Sciences Erciyes University  Kayseri Turkey"},{"name":"Faculty of Medicine, Department of Internal Medicine Erciyes University  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf167"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883\u2010025\u201001290\u20102"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20042813"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.7998"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26020746"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2025.1559499"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13070788"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201086231\u20100"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.800950"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/tjb\u20102022\u20100200"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/18.6.499"},{"issue":"2","key":"e_1_2_11_13_1","first-page":"8","article-title":"Hemodiyaliz Hastalar\u0131nda Plazma Malondialdehit ve Tiyol Seviyeleri","volume":"13","author":"\u00d6z\u015fahin E. 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