{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:57:36Z","timestamp":1785455856837,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Iron\u2010based phosphate binders (IBPBs) are used for the treatment of hyperphosphatemia. However, the erythropoiesis effects of IBPB treatment in peritoneal dialysis (PD) patients have not been fully investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective, observational study included 75 PD patients. Various parameters were compared during the first 6\u2009months of IBPB administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>While transferrin saturation, ferritin, hemoglobin (Hb), and mean corpuscular hemoglobin (MCH) increased significantly, red blood cell (RBC) count had no significant change and erythropoiesis\u2010stimulating agent (ESA) doses decreased significantly after 6\u2009months of IBPB administration. Furthermore, even in patients whose ESA dose had not changed by 2\u2009months after starting IBPB administration, Hb, RBC count, and MCH were significantly increased at the second month.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Regardless of the type of IBPB, administration of IBPB resulted in significant iron supplementation and Hb elevation, and the mechanism behind this was not only the increase in MCH due to iron supplementation but also an increase in RBC counts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1744-9987.70097","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T07:33:50Z","timestamp":1763969630000},"page":"90-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationship Between Iron\u2010Based Oral Phosphate Binders and Erythropoiesis in Peritoneal Dialysis Patients"],"prefix":"10.1111","volume":"30","author":[{"given":"Shigeki","family":"Kojima","sequence":"first","affiliation":[{"name":"Kojima Kidney and Dialysis Clinic  Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Kohatsu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology and Hypertension St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Division of Nephrology Gyotoku General Hospital  Ichikawa Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yugo","family":"Shibagaki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology and Hypertension St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohisa","family":"Tomosugi","sequence":"additional","affiliation":[{"name":"Division of Systems Bioscience for Drug Discovery, Project Research Center, Medical Research Institute Kanazawa Medical University  Kahoku Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Sakurada","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology and Hypertension St. Marianna University School of Medicine  Kawasaki Kanagawa 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