{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T19:03:24Z","timestamp":1787857404808,"version":"build-2784847793"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T00:00:00Z","timestamp":1378857600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Integrative Zoology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mature and healthy male house rats,<jats:italic>Rattus rattus<\/jats:italic>(<jats:italic>n<\/jats:italic>= 160) were fed on bait (cracked wheat: powdered sugar, 98:2) containing different concentrations of triptolide (0.1, 0.05, 0.025 and 0%) for 7 and 14 days in no\u2010choice and bi\u2010choice feeding tests in the laboratory. The objective of the study was to record the antifertility affects of triptolide after 30 and 60 days of termination of treatment. Results revealed no significant effect of triptolide treatment on weights of testis, epididymis, seminal vesicles and prostate gland of rats. Overall, sperm motility, live sperm count, sperm density and sperm morphology in the cauda epididymal fluid were found to differ significantly (<jats:italic>P<\/jats:italic>\u2264 0.05) between untreated and treated groups of rats. The major effect of triptolide on sperm morphology was in the form of sperm head tail separation, which was up to 56.0% in rats treated for 14 days in no\u2010choice and autopsied after 30 days. A significant effect (<jats:italic>P<\/jats:italic>\u2264 0.05) of triptolide treatment was observed on the histomorphology of the testis, which included a dose\u2010dependent decrease in diameter of seminiferous tubules, thickness of germinal epithelium and numbers of various spermatogenic cells. Cell associations in the seminiferous epithelial cycle were poorly developed in rats ingesting medium (4.7\u20135.1 mg\/100 g bw) and high doses (6.9\u20137.2 mg\/100 g bw) of triptolide than rats ingesting low doses (1.8\u20132.3 mg\/100 g bw) and untreated rats. The cell stages affected had not recovered fully within the 60 day period following triptolide withdrawal. The present study suggests the potential of triptolide in reproductive management of<jats:italic>Rattus rattus<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/1749-4877.12013","type":"journal-article","created":{"date-parts":[[2012,12,6]],"date-time":"2012-12-06T13:59:29Z","timestamp":1354802369000},"page":"260-276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Potential of triptolide in reproductive management of the house rat,<i>Rattus rattus<\/i>"],"prefix":"10.1111","volume":"8","author":[{"given":"Neena","family":"SINGLA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaganpreet","family":"KAUR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhupinder Kaur","family":"BABBAR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhupinder Singh","family":"SANDHU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090940210"},{"key":"e_1_2_1_3_1","first-page":"421","article-title":"Antifertility effect of Andrographis paniculata (Nees) in male albino rat","volume":"28","author":"Akbarsha MA","year":"1990","journal-title":"Indian Journal of Expermental Biology"},{"key":"e_1_2_1_4_1","first-page":"57","article-title":"Histomorphometric, and, histopathological studies on the effect of Calotropis procera (giant milkweed) on the male reproductive organs of wistar rats","volume":"5","author":"Akinloye AK","year":"2002","journal-title":"African Journal of Biomedical Research"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1120230108"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001100106"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.1997.tb02446.x"},{"key":"e_1_2_1_8_1","first-page":"172","article-title":"Ultrastructural alterations in testes from rats treated with cysteine","volume":"6","author":"Bernacchi AS","year":"1993","journal-title":"Biomedical, and, Environmental Science"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1051\/rnd:19800607"},{"key":"e_1_2_1_10_1","first-page":"127","volume-title":"Rodent Pests, and, their Control","author":"Buckle AP","year":"1994"},{"key":"e_1_2_1_11_1","first-page":"215","volume-title":"Ecologically\u2010based Rodent Management","author":"Chambers LK","year":"1999"},{"key":"e_1_2_1_12_1","first-page":"20","article-title":"The effect of Tripterygium wilfordii monomers T4, T7, T15, and, triptolide on rat nuclear protein","volume":"16","author":"Dai W","year":"1994","journal-title":"Zhongguo Yixue Kexue Yuan Xuebao"},{"key":"e_1_2_1_13_1","first-page":"155","article-title":"Studies on the chemical constituents of Tripterygium wilfordii Hook. f. 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