{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T13:33:26Z","timestamp":1769693606796,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T00:00:00Z","timestamp":1492732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Integrative Zoology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fertility control is an alternative strategy to traditional culling for the management of rodent pests. Previous studies have demonstrated that quinestrol is a potential contraceptive for male rodents, but the recovery of fertility in quinestrol\u2010treated rodents has not been evaluated. This study used C57BL\/6J mice to evaluate the recovery rate of male fertility after the administration of quinestrol. Diethylstilbestrol (DES), a non\u2010steroid estrogenic compound, was used for comparison. Different groups of mice were treated with 1 mg\/kg quinestrol, 1 mg\/kg DES, or castor oil separately for 7 days. These mice were then killed on days 8, 22 and 50 respectively. Our results indicated that the weight of epididymides and seminal vesicles decreased significantly on days 8 and 22 in quinestrol\/DES\u2010treated mice, with extensive histological changes in the seminiferous tubules. Sperm concentrations in the cauda epididymal fluid were significantly reduced on days 8 and 22 in both quinestrol and DES treatment groups and on day 50 for the DES, but not the quinestrol group. Further analysis revealed that DES\u2010treated mice exhibited a higher proportion of abnormal sperm accumulation in the epididymis, indicating that the normal sperm transportation to the cauda epididymis was blocked. Our results indicate that the anti\u2010fertility effects on male mice given quinestrol were of shorter duration than for those receiving DES at the dose of 1 mg\/kg body weight.<\/jats:p>","DOI":"10.1111\/1749-4877.12236","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T19:53:16Z","timestamp":1473450796000},"page":"250-259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Recovery of fertility in quinestrol\u2010treated or diethylstilbestrol\u2010treated mice: Implications for rodent management"],"prefix":"10.1111","volume":"12","author":[{"given":"Ming","family":"LIU","sequence":"first","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology, Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongcan","family":"LUO","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology, Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"WANG","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology, Chinese Academy of Sciences  Beijing China"},{"name":"University of the Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangming","family":"CAO","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology, Chinese Academy of Sciences  Beijing China"},{"name":"University of the Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanling","family":"WANG","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology, Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,21]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.05.052"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet0069"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0002"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1749-4877.12149"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/01480545.2014.884111"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2014.09.012"},{"key":"e_1_2_2_8_1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/FJC.0b013e3181d64b33","article-title":"Diethylstilbestrol and other nonsteroidal estrogens: novel class of store\u2010operated calcium channel modulators","volume":"55","author":"Dobrydneva Y","year":"2010","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1749-4877.12018"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0970039"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.1010483"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0b013e32834b7e7c"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M402195200"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.3.672"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/37352"},{"key":"e_1_2_2_16_1","first-page":"321","article-title":"Effect of levonorgestrel\u2010quinestrol on fertility of female Mongolia gerbils Meriones unguiculatus","volume":"34","author":"Huo X","year":"2007","journal-title":"Acta Phytophylacica Sinica"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod58.1.152"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1749-4877.12130"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.2302"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD10221"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4877.2012.00296.x"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408410902989837"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.02.010"},{"key":"e_1_2_2_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2664.2007.01287.x"},{"key":"e_1_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.1.35"},{"key":"e_1_2_2_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp970"},{"key":"e_1_2_2_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(00)00363-0"},{"key":"e_1_2_2_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/1749-4877.12013"},{"key":"e_1_2_2_29_1","first-page":"17","volume-title":"Ecologically Based Management of Rodent Pests","author":"Singleton GR","year":"1999"},{"key":"e_1_2_2_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/es991335n"},{"key":"e_1_2_2_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5431.1259"},{"key":"e_1_2_2_32_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0463.2001.090504.x"},{"key":"e_1_2_2_33_1","first-page":"115","volume-title":"Rodent outbreaks: ecology and impacts","author":"Sudarmaji","year":"2010"},{"key":"e_1_2_2_34_1","first-page":"105","article-title":"Reversal of breast cancer resistance protein\u2010mediated drug resistance by estrogen antagonists and agonists","volume":"2","author":"Sugimoto Y","year":"2003","journal-title":"Molecular Cancer Therapeutics"},{"key":"e_1_2_2_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0045-6535(99)00556-1"},{"key":"e_1_2_2_36_1","doi-asserted-by":"publisher","DOI":"10.5812\/jjm.9537"},{"key":"e_1_2_2_37_1","first-page":"392","article-title":"Effect of the contraceptive compound (EP\u20101) on reproduction of the Djungarian hamster (Phodopus campbelli) in the typical steppe","volume":"26","author":"Wan X","year":"2006","journal-title":"Acta Theriologica Sinica"},{"key":"e_1_2_2_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-013-1941-1"},{"key":"e_1_2_2_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3800(00)00308-2"},{"key":"e_1_2_2_40_1","first-page":"341","article-title":"Effect of a contraceptive compound (EP\u20101) on fertility of female Brandt's voles, gray hamsters and mid\u2010day gerbils","volume":"50","author":"Zhang Z","year":"2004","journal-title":"Acta Zoologica Sinica"},{"key":"e_1_2_2_41_1","first-page":"269","article-title":"Effect of a contraceptive compound on reproduction of greater long\u2010tailed hamsters (Tscherskia triton) in experimental enclosures","volume":"25","author":"Zhang Z","year":"2005","journal-title":"Acta Theriologica Sinica"},{"key":"e_1_2_2_42_1","first-page":"300","article-title":"Effects of a contraceptive compound (EP\u20101) on reproductive organs of male greater long\u2010tailed hamsters (Tscherskia triton)","volume":"26","author":"Zhang Z","year":"2006","journal-title":"Acta Theriologica Sinica"},{"key":"e_1_2_2_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4877.2007.00059.x"}],"container-title":["Integrative Zoology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1749-4877.12236","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1749-4877.12236","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1749-4877.12236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T04:04:39Z","timestamp":1696219479000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1749-4877.12236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,21]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/1749-4877.12236"],"URL":"https:\/\/doi.org\/10.1111\/1749-4877.12236","archive":["Portico"],"relation":{},"ISSN":["1749-4877","1749-4877"],"issn-type":[{"value":"1749-4877","type":"print"},{"value":"1749-4877","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,21]]},"assertion":[{"value":"2017-04-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}