{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:29:17Z","timestamp":1787495357095,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Integr. Zool."],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The emergence of multidrug resistance (MDR) in\n                    <jats:italic>Proteus mirabilis<\/jats:italic>\n                    clinical isolates is a growing public health concern and has serious implications for wildlife. What is the role of wildlife has been become one of the hot issues in disseminating antimicrobial resistance. Here, 54\n                    <jats:italic>P. mirabilis<\/jats:italic>\n                    isolates from 12 different species were identified. Among them, 25 isolates were determined to be MDR by profile of antimicrobial susceptibility; 10 MDR\n                    <jats:italic>P. mirabilis<\/jats:italic>\n                    isolates were subjected to comparative genomic analysis by whole genome sequencing. Comprehensive analysis showed that chromosome of\n                    <jats:italic>P. mirabilis<\/jats:italic>\n                    isolates mainly carries multidrug\u2010resistance complex elements harboring resistance to carbapenem genes\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>OXA\u20101<\/jats:sub>\n                    ,\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>NDM\u20101<\/jats:sub>\n                    , and\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>TEM\u20101<\/jats:sub>\n                    . Class I integron is the insertion hotspot of IS\n                    <jats:italic>26<\/jats:italic>\n                    ; it can be inserted into type I integron at different sites, thus forming a variety of multiple drug resistance decision sites. At the same time, Tn\n                    <jats:italic>21<\/jats:italic>\n                    , Tn\n                    <jats:italic>7<\/jats:italic>\n                    , and SXT\/R391 mobile elements cause widespread spread of these drug resistance genes. In conclusion,\n                    <jats:italic>P. mirabilis<\/jats:italic>\n                    isolates from wildlife showed higher resistance to commonly used clinic drugs comparing to those from human. Therefore, wild animals carrying MDR clinical isolates should be paid attention to by the public health.\n                  <\/jats:p>","DOI":"10.1111\/1749-4877.12510","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T14:08:08Z","timestamp":1606918088000},"page":"798-809","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Multidrug\u2010resistant\n                    <i>Proteus mirabilis<\/i>\n                    isolates carrying\n                    <i>bla<\/i>\n                    <sub>OXA\u20101<\/sub>\n                    and\n                    <i>bla<\/i>\n                    <sub>NDM\u20101<\/sub>\n                    from wildlife in China: increasing public health risk"],"prefix":"10.1111","volume":"16","author":[{"given":"Qian","family":"KANG","sequence":"first","affiliation":[{"name":"Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology Guangdong Academy of Science  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"WANG","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology Guangdong Academy of Science  Guangzhou Guangdong China"},{"name":"College of Veterinary Medicine Agricultural University of Hebei  Baoding Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"ZHAO","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology Guangdong Academy of Science  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"LIU","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology Guangdong Academy of Science  Guangzhou Guangdong China"},{"name":"College of Veterinary Medicine Agricultural University of Hebei  Baoding Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"JI","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology Guangdong Academy of Science  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"CHANG","sequence":"additional","affiliation":[{"name":"Institute of zoology Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianchun","family":"YANG","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology Guangdong Academy of Science  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijia","family":"HU","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology Guangdong Academy of Science  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"JIA","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Captive Wildlife Technologies Beijing Zoo  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojia","family":"WANG","sequence":"additional","affiliation":[{"name":"Chongqing Zoo  Chongqing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiagui","family":"TANG","sequence":"additional","affiliation":[{"name":"Chongqing Zoo  Chongqing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoying","family":"DONG","sequence":"additional","affiliation":[{"name":"College of Global Change and Earth System Science Beijing Normal University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guocheng","family":"HU","sequence":"additional","affiliation":[{"name":"South China Institute of Environmental Sciences Ministry of Ecology and Environment  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"WANG","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hangzhou Center of Disease Control and Prevention  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyu","family":"ZHANG","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Blood Safety and Supply Technologies Institute of Health Service and Transfusion Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"QIN","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Agricultural University of Hebei  Baoding Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengmin","family":"WANG","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology Guangdong Academy of Science  Guangzhou Guangdong 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