{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:19:26Z","timestamp":1790745566846,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["095171\/Z\/10\/Z"],"award-info":[{"award-number":["095171\/Z\/10\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Integr. Zool."],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The epidemiology of <jats:italic>Yersinia pestis<\/jats:italic>, the causative agent of plague, involves vectors and reservoirs in its transmission cycle. The passive plague surveillance in Madagascar targets mainly rodent and fleas. However, carnivores are routinely surveyed as sentinels of local plague activity in some countries. The aim of this study is to assess the use of domestic dog (<jats:italic>Canis familiaris<\/jats:italic>) as sentinel animal for field surveillance of plague in a highly endemic area in Madagascar. Cross\u2010sectional surveys of plague antibody prevalence in <jats:italic>C. familiaris<\/jats:italic> were conducted in endemic areas with contrasting histories of plague cases in humans, as well as a plague free area. Rodent capture was done in parallel to evaluate evidence for <jats:italic>Y. pestis<\/jats:italic> circulation in the primary reservoirs. In 2 sites, dogs were later re\u2010sampled to examine evidence of seroconversion and antibody persistence. Biological samplings were performed between March 2008 and February 2009. Plague antibody detection was assessed using anti\u2010F1 ELISA. Our study showed a significant difference in dog prevalence rates between plague\u2010endemic and plague\u2010free areas, with no seropositive dogs detected in the plague free area. No correlation was found between rodents and dog prevalence rates, with an absence of seropositive rodents in some area where plague circulation was indicated by seropositive dogs. This is consistent with high mortality rates in rodents following infection. Re\u2010sampling dogs identified individuals seropositive on both occasions, indicating high rates of re\u2010exposure and\/or persistence of plague antibodies for at least 9 months. Seroconversion or seropositive juvenile dogs indicated recent local plague circulation. In Madagascar, dog surveillance for plague antibody could be useful to identify plague circulation in new areas or quiescent areas within endemic zones. Within active endemic areas, monitoring of dog populations for seroconversion (negative to positive) or seropositive juvenile dogs could be useful for identifying areas at greatest risk of human outbreaks.<\/jats:p>","DOI":"10.1111\/1749-4877.12541","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T06:05:06Z","timestamp":1616047506000},"page":"886-892","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Field assessment of dog as sentinel animal for plague in endemic foci of Madagascar"],"prefix":"10.1111","volume":"16","author":[{"given":"Minoarisoa","family":"RAJERISON","sequence":"first","affiliation":[{"name":"Plague Unit Institut Pasteur de Madagascar  Antananarivo Madagascar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Voahangy","family":"ANDRIANAIVOARIMANANA","sequence":"additional","affiliation":[{"name":"Plague Unit Institut Pasteur de Madagascar  Antananarivo Madagascar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maherisoa","family":"RATSITORAHINA","sequence":"additional","affiliation":[{"name":"Epidemiology Unit Institut Pasteur de Madagascar  Antananarivo Madagascar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soanandrasana","family":"RAHELINIRINA","sequence":"additional","affiliation":[{"name":"Plague Unit Institut Pasteur de Madagascar  Antananarivo Madagascar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"CHANTEAU","sequence":"additional","affiliation":[{"name":"Plague Unit Institut Pasteur de Madagascar  Antananarivo Madagascar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"TELFER","sequence":"additional","affiliation":[{"name":"Institute of Biological and Environmental Sciences Zoology Building University of Aberdeen  United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lila","family":"RAHALISON","sequence":"additional","affiliation":[{"name":"Plague Unit Institut Pasteur de Madagascar  Antananarivo Madagascar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038630"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002382"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2502.171974"},{"key":"e_1_2_6_5_1","first-page":"237","article-title":"Surveillance and control of bubonic plague in the United States","volume":"50","author":"Barnes AM","year":"1982","journal-title":"Symposia of the Zoological Society of London"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci5040083"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2008.0075"},{"key":"e_1_2_6_8_1","first-page":"9","article-title":"Epid\u00e9miologie de la peste","volume":"35","author":"Brygoo ER","year":"1966","journal-title":"Archives de l'Institut Pasteur de Madagascar"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4000\/books.irdeditions.6582"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12270-2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0401.980114"},{"key":"e_1_2_6_12_1","first-page":"18","article-title":"La s\u00e9rologie anti\u2010F1 chez la souris OF1, test compl\u00e9mentaire pour le diagnostic de la peste humaine","volume":"64","author":"Dromigny JA","year":"1998","journal-title":"Archives de l'Institut Pasteur de Madagascar"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2307\/1382741"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ento.50.071803.130337"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.72.11.1295"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.05559-11"},{"key":"e_1_2_6_17_1","unstructured":"Official Journal of the European Union(2010).Directive 2010\/63\/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes. 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