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We found wound healing\u2010related genes experience adaptive evolution in cetaceans: (1) Three extrinsic coagulation pathway\u2010related genes\u2014tissue factor (<jats:italic>F3<\/jats:italic>), coagulation factor VII (<jats:italic>F7<\/jats:italic>), and coagulation factor X (<jats:italic>F10<\/jats:italic>)\u2014are subject to positive selection in cetaceans, which might promote efficient hemostasis after injury; positive selection in transforming growth factor\u2010beta 2 (<jats:italic>TGF\u2010\u03b22)<\/jats:italic>, transforming growth factor\u2010beta 3 (<jats:italic>TGF\u2010\u03b23<\/jats:italic>), and platelet\u2010derived growth factor D (<jats:italic>PDGFD<\/jats:italic>), which play immunological roles in wound healing, may help cetaceans enhance inflammatory response and tissue debridement. (2) Coagulation factor XII (<jats:italic>F12<\/jats:italic>) is the initiation factor in the intrinsic coagulation pathway. It had a premature stop codon mutation and was subjected to selective stress relaxation in cetaceans, suggesting that the early termination of <jats:italic>F12<\/jats:italic> may help cetaceans avoid the risk of vascular blockage during diving. (3) Fibrinogen alpha chain (FGA) and FIII, which were detected to contain the specific amino acid substitutions in marine mammals, indicating similar evolutionary mechanisms might exist among marine mammals to maintain strong wound\u2010healing ability. Thus, our research provides further impetus to study the evolution of the wound healing system in cetaceans and other marine mammals, extending knowledge of preventing coagulation disorder and atherosclerosis in humans.<\/jats:p>","DOI":"10.1111\/1749-4877.12781","type":"journal-article","created":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T04:40:27Z","timestamp":1698468027000},"page":"898-912","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Molecular evolution of wound healing\u2010related genes during cetacean secondary aquatic adaptation"],"prefix":"10.1111","volume":"19","author":[{"given":"Jieqiong","family":"KANG","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences Nanjing Normal University  Nanjing 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