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It is not known whether fish brain regions in contact with these barriers are affected by acidification. Here, we studied structural changes in medaka (\n                    <jats:italic>Oryzias melastigma<\/jats:italic>\n                    ) brain regions contacting cerebrospinal fluid (CSF) after short\u2010term (7 days) CO\n                    <jats:sub>2<\/jats:sub>\n                    exposure. The brain water content decreased significantly and the superficial structure of the pia mater was changed, but there was no obvious damage to the internal structures of the brain after seawater acidification. Seawater acidification also led to an increase in apoptosis and a decrease in the number of proliferative cells in brain areas contacting CSF. These results indicate that the structure of CSF\u2010contacting brain regions in medaka was affected by seawater acidification, and the brain responded to seawater acidification stress by increasing apoptosis and reducing proliferation.\n                  <\/jats:p>","DOI":"10.1111\/1749-4877.12872","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T11:21:20Z","timestamp":1722424880000},"page":"1306-1318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The water content, apoptosis, and proliferation of the brain in marine medaka affected by seawater acidification"],"prefix":"10.1111","volume":"20","author":[{"given":"Jinling","family":"XIE","sequence":"first","affiliation":[{"name":"National Demonstration Center for Experimental Fisheries Science Education Shanghai Ocean University  Shanghai China"},{"name":"Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education Shanghai Ocean University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baolin","family":"LI","sequence":"additional","affiliation":[{"name":"National Demonstration Center for Experimental Fisheries Science Education Shanghai Ocean University  Shanghai China"},{"name":"Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education Shanghai Ocean University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tangjian","family":"ZHOU","sequence":"additional","affiliation":[{"name":"National Demonstration Center for Experimental Fisheries Science Education Shanghai Ocean University  Shanghai China"},{"name":"Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education Shanghai Ocean University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"WANG","sequence":"additional","affiliation":[{"name":"National Demonstration Center for Experimental Fisheries Science Education Shanghai Ocean University  Shanghai China"},{"name":"Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education Shanghai Ocean University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tria.2020.100074"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199403000-00012"},{"key":"e_1_2_8_4_1","unstructured":"AnkenR BourratF(1988).Brain Atlas of the Medakafish: Oryzias latipes.INRA Paris."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-016-2548-x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1227\/neu.0000000000002000"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102901"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2010.08.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10695-024-01332-7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.092478"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3589-08.2008"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.059073"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0198-0149(87)90021-5"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00360-012-0668-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecss.2010.05.004"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-6549-2_2"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0249384"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep33216"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-016-0040-3"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-016-2454-3"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-445X(94)90047-7"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.15171\/apb.2019.024"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-020-00230-3"},{"key":"e_1_2_8_24_1","volume-title":"Principles of Neural Science","author":"Kandel ER","year":"2000"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20947"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/gcb.12179"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2017.0240"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10695-022-01112-1"},{"key":"e_1_2_8_29_1","unstructured":"LewisER WallaceDWR AllisonL(1998). 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