{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:30:40Z","timestamp":1790908240761,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072436"],"award-info":[{"award-number":["32072436"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31770455"],"award-info":[{"award-number":["31770455"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31972283"],"award-info":[{"award-number":["31972283"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31800308"],"award-info":[{"award-number":["31800308"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Integr. Zool."],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The role of miRNAs in the regulation of seasonal reproduction in rodents, particularly in relation to photoperiod changes, is still poorly understood. Previous studies on miRNA transcriptomes of striped hamster (<jats:italic>Cricetulus barabensis<\/jats:italic>) testes have indicated that the photoperiodism of testes, especially apoptosis, may be influenced by miRNAs. As a functional miRNA, cba\u2010miR\u2010222\u20103p in striped hamster testes exhibits suppression under a short photoperiod. To elucidate the potential role of testicular cba\u2010miR\u2010222\u20103p in the seasonal reproduction of striped hamsters, we exposed male striped hamsters to different photoperiods or injected miRNA agomir into the testes and observed the effects of these treatments, particularly some indicators related to apoptosis. The results showed that the levels of apoptosis in the testes increased in short daylength, accompanied by a significant decrease in cba\u2010miR\u2010222\u20103p expression and an increase in TRAF7 expression. Dual luciferase reporter assays verified the targeting relationship between cba\u2010miR\u2010222\u20103p and TRAF7 predicted by bioinformatics. In addition, the expression of TRAF7 decreased in the testes, which injected miRNA agomir, leading to inhibition of apoptosis, and the expression of key genes (<jats:italic>MEKK3<\/jats:italic>, <jats:italic>p38<\/jats:italic>, <jats:italic>p53<\/jats:italic>) in the downstream MAPK signaling pathway of TRAF7 was suppressed. These results suggest that short daylength induces testicular apoptosis in striped hamsters, and one possible mechanism is that the decreased expression of miR\u2010222\u20103p in testes reduces the repression of TRAF7 translation, thereby activating the MAPK pathway and affecting the level of testicular apoptosis. These findings reveal the potential role of miR\u2010222\u20103p in animal reproduction and provide new insights into the regulation of rodent populations.<\/jats:p>","DOI":"10.1111\/1749-4877.12918","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T14:08:22Z","timestamp":1730124502000},"page":"836-849","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["cba\u2010miR\u2010222\u20103p involved in photoperiod\u2010induced apoptosis in testes of striped hamsters by targeting TRAF7"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9514-2292","authenticated-orcid":false,"given":"Shuo","family":"WANG","sequence":"first","affiliation":[{"name":"School of Life Sciences Qufu Normal University  Qufu Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhui","family":"XU","sequence":"additional","affiliation":[{"name":"School of Life Sciences Qufu Normal University  Qufu Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingchen","family":"WANG","sequence":"additional","affiliation":[{"name":"School of Life Sciences Qufu Normal University  Qufu Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingdi","family":"WANG","sequence":"additional","affiliation":[{"name":"School of Life Sciences Qufu Normal University  Qufu Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiliang","family":"XUE","sequence":"additional","affiliation":[{"name":"School of Life Sciences Qufu Normal University  Qufu Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"WU","sequence":"additional","affiliation":[{"name":"School of Life Sciences Qufu Normal University  Qufu Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"FAN","sequence":"additional","affiliation":[{"name":"School of Life Sciences Qufu Normal University  Qufu Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"CHEN","sequence":"additional","affiliation":[{"name":"School of Life Sciences Qufu Normal University  Qufu Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laixiang","family":"XU","sequence":"additional","affiliation":[{"name":"School of Life Sciences Qufu Normal University  Qufu Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2012.682682"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-024-03395-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2011.11.011"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani12131605"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.03.012"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00044"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.09.028"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.109.080135"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-2018-0017"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.122592"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12108"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.95.025"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.11.040"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani12172290"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi-2023-0363"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11030301"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4238\/2015.October.29.10"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00484-022-02350-x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioz198"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.005"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau5905"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203868"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.09.004"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2024.05.135"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.10.017"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.03.025"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2012.09.001"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.2634"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.13336"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1302\/2046-3758.72.BJR-2017-0082.R1"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12216"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2209353119"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci9080447"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.23736\/S2724-6329.23.04835-0"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/mec.15161"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2011.08.002"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e15687"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28008"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24226"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioab164"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431x202010274"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24098363"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-017-0116-9"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.23632"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25676"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24011"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcp.2023.101911"}],"container-title":["Integrative Zoology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1749-4877.12918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T10:47:38Z","timestamp":1753354058000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1749-4877.12918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,28]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/1749-4877.12918"],"URL":"https:\/\/doi.org\/10.1111\/1749-4877.12918","archive":["Portico"],"relation":{},"ISSN":["1749-4877","1749-4877"],"issn-type":[{"value":"1749-4877","type":"print"},{"value":"1749-4877","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,28]]},"assertion":[{"value":"2024-10-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}