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Zool."],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Oxygen is a critical factor for the survival of most lifeforms, as inadequate availability disrupts internal metabolic balance. Hypoxia\u2010induced disruptions in glucose metabolism can be fatal to many animals. However, there is currently limited research on the energy metabolism of species that inhabit environments with intermittently low oxygen levels. In this study, we investigated the gluconeogenic metabolic response patterns of adult\n                    <jats:italic>Lasiopodomys brandtii<\/jats:italic>\n                    (Brandt's vole) and\n                    <jats:italic>Mus musculus<\/jats:italic>\n                    (Kunming mice) under hypoxia (10% O\n                    <jats:sub>2<\/jats:sub>\n                    , 12\u00a0h), followed by 1\u00a0h reoxygenation period. Our results indicated that, unlike\n                    <jats:italic>M. musculus<\/jats:italic>\n                    ,\n                    <jats:italic>L. brandtii<\/jats:italic>\n                    did not accumulate lactate after hypoxia treatment. This suggests that\n                    <jats:italic>L. brandtii<\/jats:italic>\n                    may deal with lactate accumulation caused by oxygen deficiency during hypoxia through the PGC\u20101\u03b1 regulated gluconeogenesis pathway of the liver, which can restore the level of anaerobic glycolytic products in the liver and blood caused by hypoxia relatively quickly and ensure the stable survival of the organism in a hypoxic environment. Intriguingly,\n                    <jats:italic>L. brandtii<\/jats:italic>\n                    also did not exhibit O\n                    <jats:sub>2<\/jats:sub>\n                    debt repayment after short\u2010time reoxygenation. Our study revealed that liver PGC\u20101\u03b1 regulating gluconeogenic metabolism in\n                    <jats:italic>L. brandtii<\/jats:italic>\n                    plays an important role in the maintenance of internal homeostasis of body acid\u2013base balance under hypoxic environments, presenting a potential mechanism for the improvement of hypoxia tolerance in\n                    <jats:italic>L. brandtii<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/1749-4877.12961","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T07:05:22Z","timestamp":1741071922000},"page":"1343-1355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hypoxia Promotes Gluconeogenesis Through PGC\u20101\u03b1 in the Liver of\n                    <i>Lasiopodomys brandtii<\/i>"],"prefix":"10.1111","volume":"21","author":[{"given":"Mengke","family":"Li","sequence":"first","affiliation":[{"name":"School of Life Sciences Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maolin","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Life Sciences Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wan","sequence":"additional","affiliation":[{"name":"School of Life Sciences Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Life Sciences Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Song","sequence":"additional","affiliation":[{"name":"School of Life Sciences Zhengzhou University  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