{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T03:30:48Z","timestamp":1792985448955,"version":"4.5.0"},"reference-count":54,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32360138"],"award-info":[{"award-number":["32360138"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32301054"],"award-info":[{"award-number":["32301054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Integr. Zool."],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Skin photoaging, primarily driven by ultraviolet B (UVB) radiation, is a complex process involving oxidative stress and autophagic dysfunction, for which effective therapeutic options remain limited. Here, we identified a novel peptide, OA\u2010AL14 (ALFWPMKKPWPESC), from the skin secretions of the frog\n                    <jats:italic>Odorrana andersonii<\/jats:italic>\n                    Boulenger, 1882, and investigated its protective effects against UVB\u2010induced photoaging. OA\u2010AL14 exhibited excellent biocompatibility and potent antioxidant activity\n                    <jats:italic>in vitro<\/jats:italic>\n                    . In a UVB\u2010irradiated mouse model, topical application of OA\u2010AL14 significantly ameliorated key features of photoaging, including erythema, pigmentation, epidermal hyperplasia, and barrier disruption. Mechanistically, OA\u2010AL14 activated the Nrf2 antioxidant pathway and restored cellular redox balance. Furthermore, transcriptomic and biochemical analyses revealed that OA\u2010AL14 induced protective autophagy via the AMPK\/mTOR signaling pathway. Inhibition of autophagy partially abrogated its protective effects, confirming the functional relevance of this mechanism. These findings establish OA\u2010AL14 as a promising multifunctional candidate for treating skin photoaging by integrating antioxidant defense and autophagy activation.\n                  <\/jats:p>","DOI":"10.1111\/1749-4877.70134","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T19:01:01Z","timestamp":1780599661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Amphibian\u2010Derived Peptide OA\u2010AL14 Alleviates UVB\u2010Induced Skin Photoaging via Autophagy Activation Mediated by the AMPK\/mTOR Pathway"],"prefix":"10.1111","author":[{"given":"Ying","family":"Peng","sequence":"first","affiliation":[{"name":"Key Laboratory of Skin and Mucosal Injury Repair, Regeneration &amp; Active Peptides of Yunnan Provincial Department of Education, Regenerative Medicine Research Center, Faculty of Basic Medical Science Kunming Medical University Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Skin and Mucosal Injury Repair, Regeneration &amp; Active Peptides of Yunnan Provincial Department of Education, Regenerative Medicine Research Center, Faculty of Basic Medical Science Kunming Medical University Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Fu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Skin and Mucosal Injury Repair, Regeneration &amp; Active Peptides of Yunnan Provincial Department of Education, Regenerative Medicine Research Center, Faculty of Basic Medical Science Kunming Medical University Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijian","family":"Kang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Skin and Mucosal Injury Repair, Regeneration &amp; Active Peptides of Yunnan Provincial Department of Education, Regenerative Medicine Research Center, Faculty of Basic Medical Science Kunming Medical University Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuye","family":"Jia","sequence":"additional","affiliation":[{"name":"Key Laboratory of Skin and Mucosal Injury Repair, Regeneration &amp; Active Peptides of Yunnan Provincial Department of Education, Regenerative Medicine Research Center, Faculty of Basic Medical Science Kunming Medical University Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Skin and Mucosal Injury Repair, Regeneration &amp; Active Peptides of Yunnan Provincial Department of Education, Regenerative Medicine Research Center, Faculty of Basic Medical Science Kunming Medical University Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Skin and Mucosal Injury Repair, Regeneration &amp; Active Peptides of Yunnan Provincial Department of Education, Regenerative Medicine Research Center, Faculty of Basic Medical Science Kunming Medical University Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexi","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Skin and Mucosal Injury Repair, Regeneration &amp; Active Peptides of Yunnan Provincial Department of Education, Regenerative Medicine Research Center, Faculty of Basic Medical Science Kunming Medical University Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Skin and Mucosal Injury Repair, Regeneration &amp; Active Peptides of Yunnan Provincial Department of Education, Regenerative Medicine Research Center, Faculty of Basic Medical Science Kunming Medical University Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuansheng","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Skin and Mucosal Injury Repair, Regeneration &amp; Active Peptides of Yunnan Provincial Department of Education, Regenerative Medicine Research Center, Faculty of Basic Medical Science Kunming Medical University Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeqiong","family":"Ru","sequence":"additional","affiliation":[{"name":"Key Laboratory of Skin and Mucosal Injury Repair, Regeneration &amp; Active Peptides of Yunnan Provincial Department of Education, Regenerative Medicine Research Center, Faculty of Basic Medical Science Kunming Medical University Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenrou","family":"Su","sequence":"additional","affiliation":[{"name":"Yunnan Characteristic Plant Extraction Laboratory Co., Ltd.  Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naixin","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Skin and Mucosal Injury Repair, Regeneration &amp; Active Peptides of Yunnan Provincial Department of Education, Regenerative Medicine Research Center, Faculty of Basic Medical Science Kunming Medical University Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Basic Medical Science Kunming Medical University  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saige","family":"Yin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Skin and Mucosal Injury Repair, Regeneration &amp; Active Peptides of Yunnan Provincial Department of Education, Regenerative Medicine Research Center, Faculty of Basic Medical Science Kunming Medical University Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chemistry in Ethnic Medicinal Resources &amp; Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicinal Endophytes, State Ethnic Affairs Commission &amp; Ministry of Education, School of Ethnic Medicine Yunnan Minzu University  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinwang","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Skin and Mucosal Injury Repair, Regeneration &amp; Active Peptides of Yunnan Provincial Department of Education, Regenerative Medicine Research Center, Faculty of Basic Medical Science Kunming Medical University Kunming Yunnan China"},{"name":"Yunnan Characteristic Plant Extraction Laboratory Co., Ltd.  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