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Zool."],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The domestic dog has emerged as a valuable model for investigating the biology of social behavior and neuropsychiatric disease, yet a comprehensive map of gene regulatory elements across the canine brain is still lacking. Here, we generated an ATAC\u2010seq atlas spanning seven major brain regions and the pituitary gland from four adult beagle dogs. We identified 251,492 putative\n                    <jats:italic>cis<\/jats:italic>\n                    \u2010regulatory elements (CREs) and found that chromatin accessibility profiles resolve anatomically distinct regions into discrete regulatory modules, including striatal, cortical\u2010associated, hypothalamic\/habenular, and pituitary groups. Region\u2010specific accessible elements were enriched predominantly in distal non\u2010coding regions and were associated with distinct transcription factor (TF) programs and biological functions. Integration with dog\u2010wolf genetic differentiation signals identified tissue\u2010specific CREs overlapping highly differentiated genomic regions, including loci linked to neuronal and neuroendocrine pathways. Cross\u2010species integration of human Genome\u2010Wide Association Study data further indicated that canine cortical\u2010associated chromatin features and striatal\u2010enriched chromatin signatures, along with genes linked to such CREs, exhibit enrichment for schizophrenia (SCZ) and bipolar disorder (BD) risk signals. Together, these findings delineate the regional\n                    <jats:italic>cis<\/jats:italic>\n                    \u2010regulatory landscape of the canine brain and support the dog as a translational model for studying the regulatory basis of neuropsychiatric disease.\n                  <\/jats:p>","DOI":"10.1111\/1749-4877.70189","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T11:01:56Z","timestamp":1790593316000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chromatin Accessibility Profiling of the Canine Brain Reveals Regulatory Programs Associated With Dog\u2010Wolf Divergence and Human Psychiatric Risk"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4853-1246","authenticated-orcid":false,"given":"Biao","family":"Deng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Genetic Evolution &amp; Animal Models and Yunnan Key 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