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Zool."],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Adaptive reprogramming to oligotrophic environments is a key evolutionary strategy for extreme\u2010habitat species. While enhanced fat storage and autophagy activation are well\u2010elucidated, the molecular basis of growth retardation remains undefined. The Qinghai\u2013Tibet Plateau shows decreasing nutrient availability with rising elevation, and its endemic\n                    <jats:italic>Schizopygopsis younghusbandi<\/jats:italic>\n                    is an ideal model for nutrient scarcity adaptation. We mimicked nutrient deficiency via in vitro low\u2010serum and in vivo starvation assays, identifying that inhibin \u03b2B acts centrally: its upregulation activates the SMAD pathway, inducing G1 phase arrest, attenuated proliferation, and reduced energy consumption. Nutrient deprivation also upregulates pdgf\u2010c to induce a fibrotic phenotype in muscle satellite cells. In vivo assays verified inhibin \u03b2B elevation, reversible upon refeeding. We established a\n                    <jats:italic>S. younghusbandi<\/jats:italic>\n                    muscle satellite cell culture system, elucidating inhibin \u03b2B\u2010mediated adaptive mechanisms. Comparative sequence analysis across eight Cyprinid species revealed high conservation (&gt;90%) of inhibin \u03b2B, suggesting evolutionary preservation. These findings uncover molecular underpinnings of high\u2010altitude schizothoracine adaptive evolution to nutrient scarcity, and broaden insights into survival strategies of organisms in extreme oligotrophic habitats.\n                  <\/jats:p>","DOI":"10.1111\/1749-4877.70199","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:21:26Z","timestamp":1790320886000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inhibin \u03b2B Mediates Oligotrophic Adaptation via Regulating Muscle Satellite Cell Proliferation and Differentiation in\n                    <i>Schizopygopsis younghusbandi<\/i>"],"prefix":"10.1111","author":[{"given":"Weiqiang","family":"Li","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of Freshwater Fish Reproduction and Development, School of Life Sciences, College of Fisheries, College of Pharmaceutical Sciences, Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City Southwest University  Chongqing P. 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