{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T19:33:07Z","timestamp":1762198387380,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T00:00:00Z","timestamp":1390435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chlorogenic acid (3\u2010O\u2010caffeoylquinic acid, CA) is the active component in several botanical beverage, vegetables, fruits, and herbal drugs. The effect of water boiling on the bioactivity of CA was studied. CA could be isomerized to 4\u2010O\u2010caffeoylquinic acid (4\u2010O\u2010CA) and 5\u2010O\u2010caffeoylquinic acid (5\u2010O\u2010CA) in decoctive extraction, and each of the isomers occupied about one\u2010third of the total caffeoylquinic acids. A novel method, using water elution of microsphere resin, was used to purify CA and its 2 isomers. The yield of CA, 4\u2010O\u2010CA, and 5\u2010O\u2010CA was 82%, 5.6%, and 50%, with the purity of 98%, 97%, and 99%, respectively. The DPPH radical scavenging assay showed that 4\u2010O\u2010CA, 5\u2010O\u2010CA, and CA exhibited similar activity. However, there was no significant difference between 4\u2010O\u2010CA and 5\u2010O\u2010CA when used against CCl\n                    <jats:sub>4<\/jats:sub>\n                    \u2010induced toxicity in hepG2 cells. Our studies show that isomerization is the main transformation of CA in boiling, and the decoction could not decrease the anti\u2010oxidant activity of CA.\n                  <\/jats:p>","DOI":"10.1111\/1750-3841.12350","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T18:50:02Z","timestamp":1390503002000},"source":"Crossref","is-referenced-by-count":10,"title":["Effects of Boiling on Chlorogenic Acid and the Liver Protective Effects of Its Main Products Against CCl\n                    <sub>4<\/sub>\n                    \u2010Induced Toxicity\n                    <i>In Vitro<\/i>"],"prefix":"10.1111","volume":"79","author":[{"given":"Shidong","family":"Kan","sequence":"first","affiliation":[{"name":"Biochemistry Programme, School of Life Sciences The Chinese Univ. of Hong Kong  Shatin N.T. Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matt Wan Man","family":"Cheung","sequence":"additional","affiliation":[{"name":"Biochemistry Programme, School of Life Sciences The Chinese Univ. of Hong Kong  Shatin N.T. Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanling","family":"Zhou","sequence":"additional","affiliation":[{"name":"Biochemistry Programme, School of Life Sciences The Chinese Univ. of Hong Kong  Shatin N.T. Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wing Shing","family":"Ho","sequence":"additional","affiliation":[{"name":"Biochemistry Programme, School of Life Sciences The Chinese Univ. of Hong Kong  Shatin N.T. Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2011.11.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.856485"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0010(20000515)80:7<1033::AID-JSFA595>3.0.CO;2-T"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2011.04.025"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf990489j"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2010.1557"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2011.02302.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2007.01.020"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2011.02213.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2003.11.004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(86)90131-X"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)90742-3"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(83)90303-4"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2621.2004.tb17848.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf000422s"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2010.1021"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph6020643"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2010.521162"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.08.016"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.19.966"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.09.114"},{"issue":"2","key":"e_1_2_7_23_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.17129\/botsci.482","article-title":"Antifungal activity of three Chilean plant extracts on Botrytis cinerea","volume":"90","author":"Vio\u2010Michaelis S","year":"2012","journal-title":"Bot Sci"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2007.11.112"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1892"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2011.03.001"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-006-0082-4"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf903388a"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2008.04.016"}],"container-title":["Journal of Food Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1750-3841.12350","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.12350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T19:08:07Z","timestamp":1762196887000},"score":1,"resource":{"primary":{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/10.1111\/1750-3841.12350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,23]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/1750-3841.12350"],"URL":"https:\/\/doi.org\/10.1111\/1750-3841.12350","archive":["Portico"],"relation":{},"ISSN":["0022-1147","1750-3841"],"issn-type":[{"type":"print","value":"0022-1147"},{"type":"electronic","value":"1750-3841"}],"subject":[],"published":{"date-parts":[[2014,1,23]]}}}