{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T23:56:03Z","timestamp":1779148563384,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Salvianolic acid A (Sal A) was considered to be the compound with highest activity in\n                    <jats:italic>Salvia miltiorrhiza<\/jats:italic>\n                    (danshen). Due to its low content in raw materials, many studies reported its preparation from salvianolic acid B (Sal B). However, the process of this transformation is still unknown. Our objective was to find the chemical change of the transformation from Sal B to Sal A. The results showed that Sal B was hydrolyzed to lithospermic acid (LA) first, and the latter was transformed into Sal A in thermal aqueous solution. The radical scavenging ability of Sal A, Sal B, and LA was tested through DPPH, and Sal A showed higher radical elimination ability compared to Sal B and LA.\n                    <jats:italic>In vitro<\/jats:italic>\n                    liver damage was induced by CCl\n                    <jats:sub>4<\/jats:sub>\n                    in human hepatic WRL68 cell line. Sal A, Sal B, and LA showed liver protective ability in a dose\u2010dependent manner, while Sal A possessed a much higher ability compared to Sal B and LA.\n                  <\/jats:p>","DOI":"10.1111\/1750-3841.12415","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T20:03:50Z","timestamp":1396382630000},"source":"Crossref","is-referenced-by-count":17,"title":["Transformation of Salvianolic Acid B to Salvianolic Acid A in Aqueous Solution and the\n                    <i>In Vitro<\/i>\n                    Liver Protective Effect of the Main Products"],"prefix":"10.1111","volume":"79","author":[{"given":"Shidong","family":"Kan","sequence":"first","affiliation":[{"name":"State Key Lab of New Drug and Pharmaceutical Processes, Shanghai Inst. of Pharmaceutical Industry  Nr. 1320, West Beijing Rd Shanghai 200040 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhouzhou","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Lab of New Drug and Pharmaceutical Processes, Shanghai Inst. of Pharmaceutical Industry  Nr. 1320, West Beijing Rd Shanghai 200040 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Shao","sequence":"additional","affiliation":[{"name":"State Key Lab of New Drug and Pharmaceutical Processes, Shanghai Inst. of Pharmaceutical Industry  Nr. 1320, West Beijing Rd Shanghai 200040 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji'an","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Lab of New Drug and Pharmaceutical Processes, Shanghai Inst. of Pharmaceutical Industry  Nr. 1320, West Beijing Rd Shanghai 200040 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2011.02381.x"},{"key":"e_1_2_7_3_1","first-page":"A19","article-title":"Role of reactive oxygen species (ROS) and TGF\u2010beta in tenofovir\u2010induced renal tubular toxicity","volume":"15","author":"Cotter EJ","year":"2010","journal-title":"Antivir Ther"},{"key":"e_1_2_7_4_1","first-page":"39","article-title":"Traditional Chinese medicine and related active compounds against hepatitis B virus infection","volume":"4","author":"Cui XY","year":"2010","journal-title":"Biosci Trends"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/508938"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.02.051"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2009.02.084"},{"key":"e_1_2_7_8_1","first-page":"885","article-title":"Biotransformation of Salvianolic acid B by Fusarium oxysporum f. sp Cucumerinum and Its Two Degradation Routes","volume":"7","author":"Kan SD","year":"2012","journal-title":"Nat Prod Commun"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756360802167754"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2012.06.015"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(92)90271-J"},{"key":"e_1_2_7_12_1","first-page":"805","article-title":"Isolation of Salvianolic acid A, a minor phenolic carboxylic acid of salvia miltiorrhiza","volume":"5","author":"Lu LY","year":"2010","journal-title":"Nat Prod Comm"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(01)00415-0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2006.272"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2010.521162"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf970031m"},{"key":"e_1_2_7_17_1","first-page":"29","article-title":"Thiazolidinediones induce glioma toxicity: involvement of mitochondria and ROS","volume":"94","author":"Spagnolo A","year":"2005","journal-title":"J Neurochem"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2012.09.004"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2012.723200"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X07004709"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7835.2007.00020.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2011.598457"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2007.06.034"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/534548"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf901462s"},{"key":"e_1_2_7_26_1","first-page":"484a","article-title":"The multikinase\u2010inhibitor sorafenib prevents neoangiogenesis and higher no production by the hepatic artery in CCl4\u2010induced liver cirrhosis","volume":"50","author":"Zipprich A","year":"2009","journal-title":"Hepatology"}],"container-title":["Journal of Food Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1750-3841.12415","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.12415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T19:00:07Z","timestamp":1762196407000},"score":1,"resource":{"primary":{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/10.1111\/1750-3841.12415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/1750-3841.12415"],"URL":"https:\/\/doi.org\/10.1111\/1750-3841.12415","archive":["Portico"],"relation":{},"ISSN":["0022-1147","1750-3841"],"issn-type":[{"value":"0022-1147","type":"print"},{"value":"1750-3841","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4]]}}}