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Six\u2010week\u2010old male Sprague\u2010Dawley rats were randomly divided into 5 groups: normal control (NC), diabetic control (DBC), diabetic xylitol 2.5% (DXL2.5), diabetic xylitol 5.0% (DXL5), and diabetic xylitol 10.0% (DXL10). Diabetes was induced only in the animals in DBC and DXL groups and considered diabetic when their nonfasting blood glucose level was &gt;300 mg\/dL. The DXL groups were fed with 2.5%, 5.0%, and 10% xylitol solution, whereas the NC and DBC groups were supplied with normal drinking water. After 4\u2010wk intervention, body weight, food and fluid intake, blood glucose, serum fructosamine, liver glycogen, serum alanine transaminase, aspartate transaminase, lactate dehydrogenase, creatine kinase, uric acid, creatinine, and most serum lipids were significantly decreased, and serum insulin concentration, glucose tolerance ability, and pancreatic islets morphology were significantly improved in the DXL10 group compared to the DBC group. The data of this study suggest that 10% xylitol has the better antidiabetic effects compared to 2.5% and 5.0% and it can be used as an excellent antidiabetic sweetener and food supplement in antidiabetic foods.<\/jats:p>","DOI":"10.1111\/1750-3841.12520","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T18:24:10Z","timestamp":1403634250000},"source":"Crossref","is-referenced-by-count":35,"title":["Xylitol Improves Pancreatic Islets Morphology to Ameliorate Type 2 Diabetes in Rats: A Dose Response Study"],"prefix":"10.1111","volume":"79","author":[{"given":"Md. Atiar","family":"Rahman","sequence":"first","affiliation":[{"name":"Biomedical Research Lab Dept. of Biochemistry School of Life Sciences Univ. of KwaZulu\u2010Natal (Westville Campus)  Durban 4000 South Africa"},{"name":"Dept. of Biochemistry and Molecular Biology Univ. of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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