{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:38:21Z","timestamp":1769085501873,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T00:00:00Z","timestamp":1410480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Resveratrol has a beneficial effect of lowering reactive oxygen species (ROS) and reduces cellular oxidative stress. We hypothesized that ethanol extract of\n                    <jats:italic>Smilax china<\/jats:italic>\n                    root (EESC) rich in resveratrol (RES) and oxyresveratrol (OXY) could reduce ROS caused by nicotine and promoting nicotine turnover by induction of CYP2A6. The amount of cotinine converted from nicotine was quantified by the direct barbiturate assay method. Expression of CYP2A6 was unregulated by RES, OXY, or EESC, respectively. Pretreatment of RES (50, 100, and 250 \u03bcM), OXY (50, 100, and 250 \u03bcM), and RES+OXY (50 and 100 \u03bcM) inhibited cytotoxicity and ROS production caused by nicotine in a dose\u2010dependent manner. EESC pretreatment (1.8 mg\/mL) increased cell viability by 1.5\u2010fold higher than the control (nicotine only), and lowered cellular ROS levels. A significant amount of the conversion of nicotine to cotinine was observed in EESC pretreatment by CYP2A6 induction in HepG2 cells. These results suggested that hepatic induction of CYP2A6 and ROS reduction by EESC activate nicotine metabolism and reduce cellular oxidative stress.\n                  <\/jats:p>","DOI":"10.1111\/1750-3841.12595","type":"journal-article","created":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T16:52:23Z","timestamp":1410540743000},"source":"Crossref","is-referenced-by-count":12,"title":["<i>Smilax China<\/i>\n                    Root Extract Detoxifies Nicotine by Reducing Reactive Oxygen Species and Inducing CYP2A6"],"prefix":"10.1111","volume":"79","author":[{"given":"Kyeong\u2010Mu","family":"Kim","sequence":"first","affiliation":[{"name":"Dept. of Food Science and Technology Sejong Univ  98 Gunja\u2010dong Seoul 143\u2010747 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo\u2010Won","family":"Suh","sequence":"additional","affiliation":[{"name":"Center for Nutraceutical and Pharmaceutical Materials and Div. of Bioscience and Bioinformatics 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