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However, the role of maintaining muscle mass during weight loss and as we age is an emerging concept, having implications in chronic disease prevention, functional capacity, and quality of life. Higher\u2010protein diets have been shown to: (1) promote gains in muscle mass, especially when paired with resistance training; (2) spare muscle mass loss during caloric restriction; and (3) attenuate the natural loss of muscle mass that accompanies aging. Protein quality is important to the gain and maintenance of muscle mass. Protein quality is a function of protein digestibility, amino acid content, and the resulting amino acid availability to support metabolic function. Whey protein is one of the highest\u2010quality proteins given its amino acid content (high essential, branched\u2010chain, and leucine amino acid content) and rapid digestibility. Consumption of whey protein has a robust ability to stimulate muscle protein synthesis. In fact, whey protein has been found to stimulate muscle protein synthesis to a greater degree than other proteins such as casein and soy. This review examines the existing data supporting the role for protein consumption, with an emphasis on whey protein, in the regulation of muscle mass and body composition in response to resistance training, caloric restriction, and aging.<\/jats:p>","DOI":"10.1111\/1750-3841.12802","type":"journal-article","created":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T14:05:48Z","timestamp":1425996348000},"source":"Crossref","is-referenced-by-count":251,"title":["Supplemental Protein in Support of Muscle Mass and Health: Advantage Whey"],"prefix":"10.1111","volume":"80","author":[{"given":"Michaela C.","family":"Devries","sequence":"first","affiliation":[{"name":"Exercise Metabolism Research Group (EMRG) Dept. of Kinesiology McMaster Univ  1280 Main St. W, IWC E210 Hamilton ON L8S 4K1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart M.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Exercise Metabolism Research Group (EMRG) Dept. of Kinesiology McMaster Univ  1280 Main St. W, IWC E210 Hamilton ON L8S 4K1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2011.269"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2004.07.012"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.10.2413"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.3.856S"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00590.2013"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.139840"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2013.05.021"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2013.01.014"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1997.273.1.E122"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-005-0127-z"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.26.14930"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.5.1308"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511006271"},{"issue":"3","key":"e_1_2_8_15_1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1123\/ijsnem.16.3.233","article-title":"Effect of whey and soy protein supplementation combined with resistance training in young adults","volume":"16","author":"Candow DG","year":"2006","journal-title":"Int J Sport Nutr Exerc Metab"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.037556"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.037119"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.068775"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.278"},{"issue":"2","key":"e_1_2_8_20_1","first-page":"284","article-title":"Effects of leucine and whey protein supplementation during eight weeks of unilateral resistance training","volume":"20","author":"Coburn JW","year":"2006","journal-title":"J Strength Cond Res"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-11-105"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1123\/ijsnem.16.5.494"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.3.376"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2640fje"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-014-0465-9"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.15.3.318"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1550-2783-6-8"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.04.007"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00582.2007"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00402.2005"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00301.x"},{"key":"e_1_2_8_32_1","unstructured":"FAO\/WHO Expert Consultation.1991.Protein quality evaluation report of the Joint FAO\/WHO Expert Consultation held in Bethseda Md. 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