{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:37:39Z","timestamp":1780598259193,"version":"3.54.1"},"reference-count":57,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["R37EB002641"],"award-info":[{"award-number":["R37EB002641"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Dietary patterns with cardiovascular benefits have been recommended, but the relative contributions of individual foods and food components, alone or in combination, remain undefined. Male ApoE\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice were fed either a purified AIN\u201093G control diet, a Western diet (WD), or a WD with 10% tomato powder (TP), 2% soy germ (SG), or the combination, for 4 wk (\n                    <jats:italic>n<\/jats:italic>\n                    = 10 per group). Plasma total cholesterol and triglycerides were measured with enzymatic colorimetric kits, and serum amyloid A (SAA) was measured by ELISA. Liver lipids were extracted with chloroform:methanol, and triglycerides, free and esterified cholesterol measured with enzymatic colorimetric kits. Expression of Cyp27a1, Cyp7a1, Abcg5, and Abcg8 in the liver was determined by quantitative polymerase chain reaction. Sections of the aortic root and aorta were cut and stained with hematoxylin and eosin (H&amp;E) to assess extent of atherosclerotic lesions. WD\u2010fed animals had greater liver and adipose weights, plasma cholesterol and SAA, hepatic lipids, and atherosclerosis than AIN\u201093G animals. TP and SG did not decrease atherosclerosis as measured by H&amp;E\u2010stained sections of the aortic root, aortic arch, and descending aorta. The TP diets further increased plasma cholesterol, but also led to increased expression of the Abcg5\/8 transporters involved in cholesterol efflux. Addition of SG alone to the WD attenuated WD\u2010induced increases in plasma cholesterol, liver lipids, and gonadal adipose weight. The results of this study do not support the use of either TP or SG for reduction of atherosclerosis, but suggest some beneficial effects of SG on lipid metabolism in this model of cardiovascular disease.\n                  <\/jats:p>","DOI":"10.1111\/1750-3841.12968","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T09:37:16Z","timestamp":1436866636000},"source":"Crossref","is-referenced-by-count":9,"title":["Effects of Tomato and Soy Germ on Lipid Bioaccumulation and Atherosclerosis in ApoE\n                    <sup>\u2212\/\u2212<\/sup>\n                    Mice"],"prefix":"10.1111","volume":"80","author":[{"given":"Brendon W.","family":"Smith","sequence":"first","affiliation":[{"name":"Div. of Nutritional Sciences Univ. of Illinois at Urbana\u2010Champaign  IL U.S.A"},{"name":"Bioacoustics Research Laboratory, Dept. of Electrical and Computer Engineering Univ. of Illinois at Urbana\u2010Champaign  IL U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita J.","family":"Miller","sequence":"additional","affiliation":[{"name":"Bioacoustics Research Laboratory, Dept. of Electrical and Computer Engineering Univ. of Illinois at Urbana\u2010Champaign  IL U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth R.","family":"Wilund","sequence":"additional","affiliation":[{"name":"Div. of Nutritional Sciences Univ. of Illinois at Urbana\u2010Champaign  IL U.S.A"},{"name":"Dept. of Kinesiology Univ. of Illinois at Urbana\u2010Champaign  IL U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"William D.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Div. of Nutritional Sciences Univ. of Illinois at Urbana\u2010Champaign  IL U.S.A"},{"name":"Bioacoustics Research Laboratory, Dept. of Electrical and Computer Engineering Univ. of Illinois at Urbana\u2010Champaign  IL U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"John W.","family":"Erdman","sequence":"additional","affiliation":[{"name":"Div. of Nutritional Sciences Univ. of Illinois at Urbana\u2010Champaign  IL U.S.A"},{"name":"Dept. of Food Science and Human Nutrition Univ. of Illinois at Urbana\u2010Champaign  IL U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"issue":"7","key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1093\/jn\/136.7.1886","article-title":"A diet rich in green and yellow vegetables inhibits atherosclerosis in mice","volume":"136","author":"Adams MR","year":"2006","journal-title":"J Nutr"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000042202.42136.D0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710335105"},{"issue":"6","key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"1691S","DOI":"10.1093\/ajcn\/71.6.1691S","article-title":"Lycopene and cardiovascular disease","volume":"71","author":"Arab L","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.152322"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2012.04.077"},{"issue":"6","key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1093\/jn\/130.6.1613","article-title":"Tissue lycopene concentrations and isomer patterns are affected by androgen status and dietary lycopene concentration in male F344 rats","volume":"130","author":"Boileau TW","year":"2000","journal-title":"J Nutr"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2012.10.004"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.5.1226"},{"issue":"2","key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1158\/0008-5472.CAN-06-3462","article-title":"Combinations of tomato and broccoli enhance antitumor activity in Dunning r3327\u2010h prostate adenocarcinomas","volume":"67","author":"Canene\u2010Adams K","year":"2007","journal-title":"Cancer Res"},{"key":"e_1_2_6_12_1","unstructured":"CheslerEJ PhilipVM VoyBH.2014.Multi\u2010system assessment of 8 inbred founder strains and 54 F1 hybrids of the collaborative cross. 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