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Resveratrol decreased t\u2010HSC\/Cl\u20106 cell viability at much lower concentrations within 24 h. Resveratrol pretreatment also decreased the LPS\u2010induced protein expression of \u03b1\u2010SMA and collagen I. In addition, resveratrol significantly reduced the protein expression of Toll\u2010like receptor 4 (TLR4) and myeloid differentiation primary response gene 88 (MyD88), and the expression of phosphorylated phosphatidylinositol 3\u2010kinase (PI3K) and phosphorylated serine\/threonine kinase B (Akt). Moreover, resveratrol markedly blocked the translocation of nuclear factor (NF)\u2010\u03baB in LPS\u2010activated HSCs. Furthermore, resveratrol inhibited HSCs activation through stimulating LXR\u03b2, but did not influence LXR\u03b1. Overall, we conclude that the antifibrotic effect of resveratrol is the result of blocking NF\u2010\u03baB activation and PI3K\/Akt phosphorylation, which inhibits HSC activation to obstruct liver fibrosis. Thus, resveratrol may be a natural agent for preventing hepatic fibrosis.<\/jats:p>","DOI":"10.1111\/1750-3841.13157","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T11:10:14Z","timestamp":1448622614000},"source":"Crossref","is-referenced-by-count":44,"title":["Resveratrol Regulates Activated Hepatic Stellate Cells by Modulating NF\u2010\u03baB and the PI3K\/Akt Signaling Pathway"],"prefix":"10.1111","volume":"81","author":[{"given":"De\u2010Quan","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory for Natural Resource of Changbai Mountain &amp; Functional Molecules, Ministry of Education, College of Pharmacy Yanbian Univ  Yanji 133002 Jilin Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Sun","sequence":"additional","affiliation":[{"name":"Dept. of Pharmacy Yanbian Univ. 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