{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:30:37Z","timestamp":1787794237524,"version":"build-2784847793"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T00:00:00Z","timestamp":1464048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Natl. Natural Science Foundation of China","award":["31401476, 31471606"],"award-info":[{"award-number":["31401476, 31471606"]}]},{"DOI":"10.13039\/501100013286","name":"Specialized Research Fund for the Doctoral Program of Higher Education","doi-asserted-by":"crossref","award":["20130132120024"],"award-info":[{"award-number":["20130132120024"]}],"id":[{"id":"10.13039\/501100013286","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This research was performed to explore the protective effect of cod skin collagen peptides (CCP) on gastric ulcer induced by acetic acid. The CCP were fractionated into low molecular CCP (LMCCP,\n                    <jats:italic>M<\/jats:italic>\n                    <jats:sub>w<\/jats:sub>\n                    &lt; 3 kDa) and high molecular CCP (HMCCP,\n                    <jats:italic>M<\/jats:italic>\n                    <jats:sub>w<\/jats:sub>\n                    &gt; 3 kDa). In HMCCP and LMCCP, glycine of accounted for about one\u2010third of the total amino acids without cysteine and tryptophan, and hydrophobic amino acids accounted for about 50%. After 21 d CCP treatment (60 or 300 mg\/kg, p.o.\/daily), the healing effects on acetic acid\u2010induced gastric ulcers were evaluated by macroscopic measure, microscopic measure, and immune histochemistry. Moreover, the expression levels of the growth factors, such as vascular endothelial growth factor, epidermal growth factor, transforming growth factor \u03b21 (TGF\u03b21), and the heat shock protein 70 (HSP70) was detected. The results showed that both LMCCP and HMCCP could significantly decrease the ulcer areas and promote the healing of the lesions. They also could improve the levels of hexosamine, glutathione, superoxide dismutase, and glutathione peroxidase, and reduce the content of malondialdehyde and inducible nitric oxide synthase. In addition, the expression level of TGF\u03b21 gene and HSP70 mRNA was significantly improved by the treatment. It suggested that CCP could be able to improve symptoms of gastric ulcer and probably be used in the treatment of gastric ulcer.\n                  <\/jats:p>","DOI":"10.1111\/1750-3841.13332","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T00:32:04Z","timestamp":1464136324000},"source":"Crossref","is-referenced-by-count":23,"title":["Protective Effect of Cod (\n                    <i>Gadus macrocephalus<\/i>\n                    ) Skin Collagen Peptides on Acetic Acid\u2010Induced Gastric Ulcer in Rats"],"prefix":"10.1111","volume":"81","author":[{"given":"Huina","family":"Niu","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering Ocean Univ. of China  No. 5, Yu Shan Road Qingdao Shandong Province 266003 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicong","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Ocean Univ. of China  No. 5, Yu Shan Road Qingdao Shandong Province 266003 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Hou","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Ocean Univ. of China  No. 5, Yu Shan Road Qingdao Shandong Province 266003 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Ocean Univ. of China  No. 5, Yu Shan Road Qingdao Shandong Province 266003 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bafang","family":"Li","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Ocean Univ. of China  No. 5, Yu Shan Road Qingdao Shandong Province 266003 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0308-8146(96)00229-4"},{"issue":"5","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1515\/znc-2006-5-605","article-title":"Antiulcerogenic activity of crude extract, fractions, and populnoic acid isolated from Austroplenckia populnea (Celastraceae)","volume":"61","author":"Andrade SF","year":"2006","journal-title":"Zeitschrift fur Naturforschung C"},{"key":"e_1_2_8_4_1","volume-title":"A prospective study of comparison between efficacy of topical sucralfate and conventional dressings in the management of chronic lower limb ulcers","author":"Aurif F.","year":"2011"},{"key":"e_1_2_8_5_1","volume-title":"Manual de t\u00e9cnicas para histologia normal e patol\u00f3gica","author":"Behmer OA","year":"1976"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80797-4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0032-9592(00)00297-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2007.09.022"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2014.11.017"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.09.026"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199110000-00006"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198611000-00018"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305-0491(93)90213-O"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2011.06.030"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.05.007"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2003.10.004"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000028258"},{"key":"e_1_2_8_19_1","doi-asserted-by":"crossref","unstructured":"KimHP MorseD ChoiAMK.2006.Heat\u2010shock proteins: new keys to the development of cytoprotective therapies. Expert opinion on therapeutic targets10(5):759\u201369.","DOI":"10.1517\/14728222.10.5.759"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.2000.0748"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.05.030"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000063394"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5309.75"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.1104"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-6997(25)06663-3"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0032-9592(02)00024-9"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jflm.2013.12.016"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.2386"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)60964-3"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90252.2008"},{"key":"e_1_2_8_31_1","unstructured":"SahooRR.2012. Antioxidant & antimicrobial efficacy of Ficus religiosa L. & Ficus benghalensis L. Plant."},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600811111"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-012-0807-2"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000171168"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2012.09.006"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90773-0"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199112001-00007"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-4257(01)00046-8"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2013.11.007"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.10.005"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1139\/y93-014"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2005.06.004"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/10498850.2011.654382"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-002-1078-3"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.2.286"},{"key":"e_1_2_8_46_1","first-page":"4452888","volume-title":"Process for producing a low\u2010molecular weight peptide composition and nutrient agent containing the same","author":"Yamazaki K","year":"1984"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2007.10.027"}],"container-title":["Journal of Food Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1750-3841.13332","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.13332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T15:55:56Z","timestamp":1762185356000},"score":1,"resource":{"primary":{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/10.1111\/1750-3841.13332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,24]]},"references-count":46,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/1750-3841.13332"],"URL":"https:\/\/doi.org\/10.1111\/1750-3841.13332","archive":["Portico"],"relation":{},"ISSN":["0022-1147","1750-3841"],"issn-type":[{"value":"0022-1147","type":"print"},{"value":"1750-3841","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,24]]}}}