{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:04:21Z","timestamp":1782601461723,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T00:00:00Z","timestamp":1485388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Natl. Natural Science Foundation of China","award":["31360552"],"award-info":[{"award-number":["31360552"]}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"crossref","award":["20151BAB204036"],"award-info":[{"award-number":["20151BAB204036"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Project Program","award":["SKLF-ZZB-201515"],"award-info":[{"award-number":["SKLF-ZZB-201515"]}]},{"name":"Excellent Young Scientist Award from Jiangxi Province","award":["No. 20153BCB23026"],"award-info":[{"award-number":["No. 20153BCB23026"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Dietary amino acids provide various beneficial effects for our health. The aim of the present study was to assess the effects of tryptophan (Trp) supplementation on barrier function. Ninety\u2010six healthy finishing pigs (initial body weight 51.49 \u00b1 1.12 kg) were randomly allocated into 2 treatment groups, control group, and 0.2% Trp group. The control group was fed the basal diet, and 0.2% Trp group was fed basal diet plus 0.2% Trp. The trial period is 60 d. Compared with control group, the mRNA abundance of claudin\u20103 and zonula occluden\u20101 (ZO\u20101) in the jejunum in 0.2% Trp group (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05) was increased. According to immunohistochemistry and immunoblotting test, the expression of ZO\u20101 in jejunum in 0.2% Trp group was also significantly increased compared with the control group (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). These results revealed that Trp enhanced the expression of tight junction protein ZO\u20101 in the intestine of pig model. Trp may be potential and beneficial dietary functional factor for regulating the intestinal development and inhibiting intestinal aging.\n                  <\/jats:p>","DOI":"10.1111\/1750-3841.13603","type":"journal-article","created":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T14:57:47Z","timestamp":1485442667000},"page":"562-567","source":"Crossref","is-referenced-by-count":46,"title":["Dietary Tryptophan Enhanced the Expression of Tight Junction Protein ZO\u20101 in Intestine"],"prefix":"10.1111","volume":"82","author":[{"given":"Wenhui","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, School of Food Science and Technology Nanchang Univ.  Nanchang 330047 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumei","family":"Mi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, School of Food Science and Technology Nanchang Univ.  Nanchang 330047 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Ruan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, School of Food Science and Technology Nanchang Univ.  Nanchang 330047 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, School of Food Science and Technology Nanchang Univ.  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