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Partial digestion of gluten generates approximately 35 amino acids (aa) immunomodulatory peptides which activate T\u2010cell\u2013mediated immune system, followed by immunological inflammation of mucosa leading to the onset of celiac disease (CD). CD is an autoimmune disease associated with HLA\u2013DQ2\/DQ8 polymorphism and dysbiosis of gut microbiota. CD is either diagnosed using duodenal mucosal biopsis or serological testing for transglutaminase 2 (TG2) specific antibodies (IgA and IgG). Current therapy for CD management is gluten\u2010free diet, while other therapies like glutenase, probiotics, immunomodulation, jamming of HLA\u2010DQ2, inhibition of TG2, and gluten tolerance aided by gluten tolerizing vaccines are being developed.<\/jats:p>","DOI":"10.1111\/1750-3841.13612","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T10:45:02Z","timestamp":1485859502000},"page":"270-277","source":"Crossref","is-referenced-by-count":78,"title":["Physiopathology and Management of Gluten\u2010Induced Celiac Disease"],"prefix":"10.1111","volume":"82","author":[{"given":"Jitendra","family":"Kumar","sequence":"first","affiliation":[{"name":"Dept. of Biochemistry M.D. Univ.  Rohtak 124001 Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Kumar","sequence":"additional","affiliation":[{"name":"Dept. of Biochemistry M.D. Univ.  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